Autonomic nervous evaluation in the early stages of olivopontocerebellar atrophy
Autonomic nervous evaluation in the early stages of olivopontocerebellar atrophy
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DOI：
10.1016/j.autneu.2005.09.004
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发表时间：
2005-12-30
影响因子：
2.7
通讯作者：
Nakagawa, M
中科院分区：
文献类型：
--
作者：
Kuriyama, N;Mizuno, T;Nakagawa, M
本文对13例橄榄桥脑小脑萎缩（OPCA）门诊患者（男7例，女6例，平均年龄51.0岁）进行了早期自主神经功能测定的临床意义。我们通过测量血压、血浆去甲肾上腺素（NE）、CVR-R、低频功率/高频功率比（L/H）、高频功率（HF）评分和使用Holier ECG记录的心率（HR）监测来评估CVR-R。我们还进行了尿动力学检查，重点是膀胱功能障碍的可能存在，尽管对照组和OPCA组之间的HR、CVR-R、L/H、血浆去甲肾上腺素水平和收缩压没有显著变化，但OPCA组的HF（高频功率）（ms（2）），特别是在夜间，总是显示出显著下降。所有表现出昼夜HF降低的OPCA患者也表现出膀胱功能障碍的倾向。目前的结果似乎与副交感神经自主神经系统和神经肌肉功能障碍在下urinarytract.In结论，HRV（心率变异性）分析是一个有用的和安全的工具和敏锐的预测评估自主神经活动的功能状态，特别是在OPCA的早期阶段。这项研究还表明，OPCA患者的尿动力学测量作为下尿路神经肌肉功能障碍和副交感神经功能障碍的指标可能有效。(c)2005 Elsevier B. V.保留所有权利。
The clinical significance of evaluating autonomic nervous system functions in the early stages of olivopontocerebellar atrophy (OPCA) has been investigated in 13 OPCA out-patients (7 males and 6 females, mean age: 51.0 years). We have employed measurements of blood pressure, plasma norepinephrine (NE), CVR-R, low-frequency power/high-frequency power ratio (L/H), high-frequency power (HF) score and heart rate (HR) monitoring using Holier ECG recording for evaluation of CVR-R. We have also carried out urodynamic examinations, focusing on the possible existence of bladder dysfunction.Although no significant changes were noted between control and OPCA groups concerning HR, CVR-R, L/H, plasma levels of norepinephrine and systolic blood pressure, HF (high-frequency power) (ms(2)), especially at night time, invariably showed a significant decline in OPCA groups. All OPCA patients who showed a decreased circadian HF also exhibited a tendency towards urinary bladder dysfunction. The present results appear to relate to disorder of the parasympathetic autonomic nervous system and neuromuscular dysfunction in the lower urinary tract.In conclusion, HRV (heart rate variability) analysis is a useful and safe tool and a keen predictor for evaluating functional states of autonomic nervous activity, especially in the early stages of OPCA. This study has also suggested the possible efficacy of urodynamic measurements in OPCA patients as an indicator of neuromuscular dysfunction in the lower urinary tract and of parasympathetic malfunction. (c) 2005 Elsevier B.V. All rights reserved.