Effects of chemical forms of gadolinium on the spleen in mice after single intravenous administration.
Effects of chemical forms of gadolinium on the spleen in mice after single intravenous administration.
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DOI：
10.1016/j.bbrep.2022.101217
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发表时间：
2022-03
影响因子：
2.7
通讯作者：
Kiyono M
中科院分区：
文献类型：
--
作者：
Nakamura R;Takanezawa Y;Ohshiro Y;Uraguchi S;Kiyono M
钆基造影剂（GBCA）被广泛用于改善磁共振成像期间的组织对比度。暴露于GBCA可导致人体组织内的钆沉积，由于游离钆（Gd 3+）的潜在毒性作用，已成为临床问题。在这里，我们报告了单次给予GBCA（Omniscan和Gadovist）和Gd 3+对小鼠组织的影响。5周龄雄性BALB/c小鼠静脉注射GBCA或Gd 3+。注射后7天，在脾脏中检测到相对高水平的钆（118.87 nmol/g组织），肝脏（83.00 nmol/g组织），皮肤（48.56 nmol/g组织）和肾脏（25.59 nmol/g组织）的Gd（NO3）3（高剂量：0.165 mmol/kg）组;骨中（11.12 nmol/g组织），肾脏（7.49 nmol/g组织），牙齿（牙齿：6.18 nmol/g组织）和皮肤（2.43 nmol/g组织）在高剂量组（1.654 mmol/kg）和高剂量组（3.308 mmol/kg）的肾脏（16.36 nmol/g组织）和皮肤（4.88 nmol/g组织）中，在Gd 3+组中观察到脾脏的包裹（p < 0.05），但在Omniscan或Gadovist组中未观察到。Gd 3+导致铁积累周围的白色髓的脾脏，这表明，扩大的脾脏是，至少部分，与Gd 3+和/或铁的积累。我们的研究结果可能有助于阐明不同类型的钆剂的相对风险，所涉及的机制，甚至认识到GBCA的潜在毒性作用。钆的化学形态对钆在组织中沉积的影响。Gd ~（3+）引起小鼠脾脏肿大和铁沉积。脾脏是Gd 3+从GBCA释放的潜在靶点。
Gadolinium-based contrast agents (GBCAs) are widely used to improve tissue contrast during magnetic resonance imaging. Exposure to GBCAs can result in gadolinium deposition within human tissues and has become a clinical concern because of the potential toxic effects of free gadolinium (Gd3+). Here, we report the impact of a single administration of GBCAs (Omniscan and Gadovist), and Gd3+ on mouse tissues. Five-week-old male BALB/c mice were injected intravenously with GBCAs or Gd3+. Seven days after injection, relatively high levels of gadolinium were detected in the spleen (118.87 nmol/g tissue), liver (83.00 nmol/g tissue), skin (48.56 nmol/g tissue), and kidneys (25.59 nmol/g tissue) of the Gd(NO3)3 (high dose: 0.165 mmol/kg) group; in the bones (11.12 nmol/g tissue), kidneys (7.49 nmol/g tissue), teeth (teeth: 6.18 nmol/g tissue), and skin (2.43 nmol/g tissue) of the Omniscan (high dose: 1.654 mmol/kg) group and in the kidneys (16.36 nmol/g tissue) and skin (4.88 nmol/g tissue) of the Gadovist (high dose: 3.308 mmol/kg) group. Enlargement of the spleen was observed in the Gd3+ group (p < 0.05), but not in the Omniscan or Gadovist groups. Gd3+ caused iron accumulation around the white pulp of the spleen, suggesting that enlargement of the spleen is, at least in part, associated with Gd3+ and/or iron accumulation. Our results may help elucidate the relative risks of different types of gadolinium agents, the mechanisms involved, and even recognition of potential toxic effects of GBCAs. The tissue deposition of gadolinium influenced by the chemical forms of gadolinium. Gd3+ causes enlargement and iron deposition in the spleen of mice. The spleen is a potential target for the release of Gd3+ from GBCAs.
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影响因子：
5.1
作者：
Liu, HX;Yuan, L;Wang, K
通讯作者：
Wang, K
影响因子：
5.6
作者：
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影响因子：
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作者：
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DOI：
10.1016/j.bbrc.2020.03.080
发表时间：
2020-05-21
影响因子：
3.1
作者：
Takanezawa, Yasukazu;Nakamura, Ryosuke;Kiyono, Masako
通讯作者：
Kiyono, Masako
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3.9
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通讯作者：
Varani, James