Preferred sites of strand scission in DNA modified by andi-diol epoxide of benzo[a]pyrene.
Preferred sites of strand scission in DNA modified by andi-diol epoxide of benzo[a]pyrene.
复制标题
苯并[a]芘的对二醇环氧化物修饰的DNA中链断裂的优选位点。
DOI：
10.1126/science.7403858
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发表时间：
1980
期刊：
影响因子：
56.9
通讯作者：
A. D'Andrea
中科院分区：
文献类型：
--
作者：
W. Haseltine;K. Lo;A. D'Andrea
用确定序列的DNA底物研究了苯并[a]芘的反二醇环氧化物修饰DNA的位置。在碱性和中性pH条件下，修饰后的DNA在鸟嘌呤、腺嘌呤和胞嘧啶位置不能发生链断裂。
The sites of DNA modification by the anti-diol epoxide of benzo[a]pyrene were investigated with the use of a DNA substrate of defined sequence. The modified DNA was labile to strand scission at alkaline and neutralpH at guanine, adenine, and cytosine positions.