The Use of the MolecuLight i:X in Managing Burns: A Pilot Study
The Use of the MolecuLight i:X in Managing Burns: A Pilot Study
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DOI：
10.1097/bcr.0000000000000565
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发表时间：
2018-01-01
影响因子：
1.4
通讯作者：
Jeffery, Steven L. A.
中科院分区：
文献类型：
--
作者：
Blumenthal, Emily;Jeffery, Steven L. A.
MolecuLight i：X成像设备是一种便携式、非侵入性、实时相机，用于可视化伤口中的细菌负荷。它使用紫光照明和双带通滤光片来捕获组织基质中内源性结构和有害细菌的荧光。MolecuLight i：X可捕捉伤口图像，并突出显示潜在的有害细菌水平。这是对MolecuLight i：X摄像机用于烧伤管理的初步评价，旨在证明以下内容：器械指导临床医生管理烧伤的能力（即，检测、识别和指定擦拭位置）。在标准光和紫光照明下拍摄烧伤伤口，以比较明显感染体征和症状的表现。获得微生物学拭子样本，以将任何细菌存在与图像相关联。荧光图像用于引导拭子到细菌聚集的地方。对20名患者进行了成像。根据图像和拭子结果，4名患者没有细菌污染。16例患者显示金黄色葡萄球菌、铜绿假单胞菌或其他细菌生长。根据定义，其中9名患者患有感染。这些发现与感染的典型体征和症状、荧光图像和微生物学结果相关。MolecuLight i：X的有效性是显而易见的，因为微生物学结果与图像相关。目前正在进行进一步的研究，以测试该设备作为早期干预工具的作用。有了这些早期结果和拭子样本的指导，MolecuLight i：X可能能够在感染和随后的移植失败之前检测细菌载量，从而缩短住院时间并改善整体愈合。
The MolecuLight i:X Imaging Device is a portable, noninvasive, real-time camera used to visualize the bacterial load in a wound. It uses violet light illumination and a dual bandpass optical filter to capture the fluorescence of endogenous structures in the tissue matrix and harmful bacteria. The MolecuLight i:X captures images of wounds and highlights potentially detrimental levels of bacteria. This is an initial evaluation of using the MolecuLight i:X camera in the management of burns to demonstrate the following: the ability of the device to guide clinicians in their management of the burn (ie, detect, identify, and specify swabbing locations). Burn wounds were photographed under standard light and violet light illumination to compare presentations of obvious infection signs and symptoms. Microbiology swab samples were obtained to correlate any bacterial presence to the images. The fluorescence images were used to guide swabs to where the bacteria were congregating. Twenty patients were imaged. Four patients did not have bacterial contamination based on their images and swab results. Sixteen patients showed growth of Staphylococcus aureus, Pseudomonas aeruginosa, or other bacteria. Nine of the patients, by definition, had infections. These findings were correlated with the typical signs and symptoms of infection, the fluorescence images, and the microbiology results. The efficacy of the MolecuLight i:X is evident due to the microbiology results correlating to the images. Further research is being done to test the device in terms of being an early intervention tool. With these early results and guidance of swab samples, the MolecuLight i:X may be able to detect bacterial load before an infection and subsequent graft failure, thereby shortening lengths of hospital stay and improving overall healing.