Frequent silence of chromosome 9p, homozygous DOCK8, DMRT1 and DMRT3 deletion at 9p24.3 in squamous cell carcinoma of the lung
Frequent silence of chromosome 9p, homozygous DOCK8, DMRT1 and DMRT3 deletion at 9p24.3 in squamous cell carcinoma of the lung
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DOI：
10.3892/ijo_00000681
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发表时间：
2010-08-01
影响因子：
5.2
通讯作者：
Park, Jong Woo
中科院分区：
文献类型：
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作者：
Kang, Ji Un;Koo, Sun Hoe;Park, Jong Woo
染色体改变是促进肺癌发展的主要基因组力量。我们对22例肺鳞状细胞癌（SCC）进行全基因组微阵列- cgh（分辨率，1 Mb），以确定可能是SCC形成或进展中重要介质的关键遗传标记。在全基因组图谱上，拷贝数损失（log(2)）比率
Chromosomal alterations are a major genomic force contributing to the development of lung cancer. We subjected 22 cases of squamous cell carcinoma of the lung (SCC) to whole-genome microarray-CGH (resolution, 1 Mb) to identify critical genetic landmarks that might be important mediators in the formation or progression of SCC. On a genome-wide profile, copy number losses (log(2) ratio