Phenanthroindolizidine alkaloids from the stems of Ficus septica
Phenanthroindolizidine alkaloids from the stems of Ficus septica
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DOI：
10.1021/np050095o
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发表时间：
2005-07-01
影响因子：
5.1
通讯作者：
Wu, TS
中科院分区：
文献类型：
--
作者：
Damu, AG;Kuo, PC;Wu, TS
从无花果茎甲醇提取物中分离出6种已知的苯并吲哚吡啶类生物碱，并分离出8种新的生物碱，分别为：ficusepines B-D（1-3）、10R、13aR-tylophorineN-oxide(4)、10R、13aR-tylocrebrine N-oxide(5)、IOS、13aR-tylocrebrine N-oxide(6)、10S、13aR-isotylocrebrine N-oxide(7)和10S、13aS-isotylocrebrine N-oxide(8)。新化合物的结构通过光谱数据解释得以阐明。利用HONE-1和NUGC细胞系体外评估了部分生物碱的细胞毒性。
In addition to six known phenanthroindolizidine alkaloids, eight new alkaloids, namely, ficuseptines B-D (1-3), 10R,13aR-tylophorineN-oxide (4), 10R,13aR-tylocrebrine N-oxide (5), IOS,13aR-tylocrebrine N-oxide (6), 10S, 13aR-isotylocrebrine N-oxide (7), and 10S, 13aS-isotylocrebrine N-oxide (8), were isolated from a methanol extract of the stems of Ficus septica. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Cytotoxicity of some of these alkaloids was assessed in vitro using the HONE-1 and NUGC cell lines.