Effect of reducing dietary advanced glycation end products on obesity-associated complications: a systematic review.
Effect of reducing dietary advanced glycation end products on obesity-associated complications: a systematic review.
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DOI：
10.1093/nutrit/nuz034
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发表时间：
2019-10
影响因子：
6.1
通讯作者：
Priscila V M Ribeiro;Juliana F Tavares;M. A. C. Costa;J. B. Mattar;R. Alfenas
中科院分区：
文献类型：
--
作者：
Priscila V M Ribeiro;Juliana F Tavares;M. A. C. Costa;J. B. Mattar;R. Alfenas
饮食中晚期糖基化终产物（AGEs）的摄入与氧化应激、炎症和其他通常与肥胖相关的慢性疾病有关。目的分析饮食中糖基化终产物对肥胖相关并发症的影响。数据来源：本系统评价按照PRISMA指南进行并报告。检索PubMed、科克伦和Scopus数据库，检索词为“晚期糖基化终末产物”、“超重”和“肥胖”。“最后一次搜索是在2018年10月进行的。资料提炼本综述包括6项评价低年龄和高年龄饮食影响的研究。研究持续时间范围为1天至12周。作者对所有汇编的数据进行了比较。资料分析除了可溶性AGEs受体外，循环和尿液AGEs标志物被认为是主要结局。次要结局为心脏代谢、炎症、血糖、人体测量和肾脏标志物。结论AGE-CRP相互作用可激活脂肪细胞NF-κB（nuclear factor kappa B）信号通路，抑制PI 3 K-AKT信号通路，可能与慢性疾病的发生有关。这种相互作用可以被认为是一种新的解释肥胖的发病机制。AGEs也可用作监测超重和肥胖人群对饮食干预反应的生物标志物。药物审查注册PROSPERO注册号CRD 42018082745。
CONTEXT Consumption of dietary advanced glycation end products (AGEs) is associated with oxidative stress, inflammation, and other chronic conditions commonly associated with obesity. OBJECTIVE To analyze the effects of dietary AGEs on complications associated with obesity. DATA SOURCES This systematic review was conducted and reported according to PRISMA guidelines. The PubMed, Cochrane, and Scopus databases were searched, using the terms "advanced glycation end products," "overweight," and "obesity." The last search was performed in October 2018. DATA EXTRACTION Six studies that evaluated the effects of low-AGE and high-AGE diets were included in the review. The duration of the studies ranged from 1 day to 12 weeks. A comparison of all the compiled data was conducted by the authors. DATA ANALYSIS Circulating and urinary AGE markers, besides soluble receptor for AGEs, were considered as the primary outcomes. The secondary outcomes were cardiometabolic, inflammatory, glycemic, anthropometric, and renal markers. CONCLUSIONS AGE-RAGE interactions can activate the NF-κB (nuclear factor kappa B) signaling pathway and inhibit the PI3K-AKT pathway in adipocytes, which may explain their association with chronic diseases. This interaction can be considered as a novel explanation for the pathogenesis of obesity. AGEs can also be used as a biomarker for monitoring responses to dietary interventions in overweight and obese people. SYSTEMATIC REVIEW REGISTRATION PROSPERO registration no. CRD42018082745.