Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction
Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction
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DOI：
10.1016/j.ajog.2010.01.012
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发表时间：
2010-06-01
影响因子：
9.8
通讯作者：
Bar, Jacob
中科院分区：
文献类型：
--
作者：
Kovo, Michal;Schreiber, Letizia;Bar, Jacob
目的：妊娠高血压/先兆子痫（PIH）和胎儿生长受限（FGR）有着共同的胎盘起源。将胎盘病变分为母体或胎儿起源的病理分类在这些疾病之间进行了比较。研究设计：妊娠合并妊高征、血压正常的FGR或两者的胎盘（合并）进行了分析，并将病变分类为符合母体灌注不足和胎儿血栓闭塞性疾病的病变。妊高征组和合并妊高征组孕妇血管病变多见（分别为61%和59%），与FGR组相比，（16.2%; P <0.001），绒毛病变在联合组中比FGR和PIH组更常见（分别为79.5%、53.5%和46.9%; P = 0.004）。FGR组中16.2%的胎儿出现绒毛改变，妊高征组中3.1%的胎儿出现绒毛改变（P = 0.03），FGR组中15.2%的胎儿出现慢性绒毛炎，妊高征组中1.6%的胎儿出现慢性绒毛炎（P = 0.004）。
OBJECTIVE: Pregnancy-induced hypertension/preeclampsia (PIH) and fetal growth restriction (FGR) share a common placental origin. The pathologic classification that divides placental lesions to maternal or fetal origin was compared between these disorders.STUDY DESIGN: Placentas from pregnancies that were complicated by PIH, normotensive FGR, or by both (combined) were analyzed, and lesions were classified as those consistent with maternal under-perfusion and with fetal thromboocclusive disease.RESULTS: Maternal vascular lesions were more common in the PIH group and combined group (61% and 59%, respectively), compared with the FGR group (16.2%; P < .001), and villous lesions were more common in the combined group, compared with the FGR and PIH groups (79.5%, 53.5%, and 46.9%, respectively; P = .004). Fetal villous changes were observed in 16.2% in the FGR group, compared with 3.1% in the PIH group (P = .03), and chronic villitis was 15.2% in the FGR group vs 1.6% in the PIH group (P = .004).CONCLUSION: Placental lesions correspond with different clinical presentations.