Complex spectral interactions encoded by auditory cortical neurons: relationship between bandwidth and pattern.
Complex spectral interactions encoded by auditory cortical neurons: relationship between bandwidth and pattern.
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DOI：
10.3389/fnsys.2010.00145
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发表时间：
2010
影响因子：
3
通讯作者：
Sutter ML
中科院分区：
文献类型：
--
作者：
O'Connor KN;Yin P;Petkov CI;Sutter ML
大多数关于听觉皮层神经元的研究关注的是相当简单的刺激的影响，例如纯音或宽带噪声，或者单个声学参数的调制。然而，将这些发现扩展到更复杂的刺激（如自然声音）中的特征编码可能很困难。从简单到更复杂情况的推广结果可能由于在复杂声音中的多个同时变化的声学参数之间发生的非线性相互作用而复杂化。为了在频域中研究这个问题，我们对清醒猕猴的初级听觉（A1）神经元的两个全局特征（频谱模式（此处为涟漪频率）和带宽）的影响进行了参数研究。大多数神经元调谐的一个或两个变量，大多数还显示带宽和模式之间的相互作用，这意味着他们的影响是有条件的或相互依赖的。光谱线性滤波器模型能够定性地再现基本效应和相互作用，这表明一个简单的神经机制可能能够解释这些相互依赖性。我们的研究结果表明，大多数A1神经元的行为可能取决于多个参数，因此大多数不太可能独立或不变地响应特定的声学特征。
The focus of most research on auditory cortical neurons has concerned the effects of rather simple stimuli, such as pure tones or broad-band noise, or the modulation of a single acoustic parameter. Extending these findings to feature coding in more complex stimuli such as natural sounds may be difficult, however. Generalizing results from the simple to more complex case may be complicated by non-linear interactions occurring between multiple, simultaneously varying acoustic parameters in complex sounds. To examine this issue in the frequency domain, we performed a parametric study of the effects of two global features, spectral pattern (here ripple frequency) and bandwidth, on primary auditory (A1) neurons in awake macaques. Most neurons were tuned for one or both variables and most also displayed an interaction between bandwidth and pattern implying that their effects were conditional or interdependent. A spectral linear filter model was able to qualitatively reproduce the basic effects and interactions, indicating that a simple neural mechanism may be able to account for these interdependencies. Our results suggest that the behavior of most A1 neurons is likely to depend on multiple parameters, and so most are unlikely to respond independently or invariantly to specific acoustic features.