CASTRATION PROLONGS TOLERANCE OF YOUNG MALE-RATS TO PULMONARY O-2 TOXICITY
CASTRATION PROLONGS TOLERANCE OF YOUNG MALE-RATS TO PULMONARY O-2 TOXICITY
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DOI：
10.1152/ajpregu.1984.247.3.r475
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发表时间：
1984-01-01
影响因子：
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通讯作者：
FRANK, L
中科院分区：
文献类型：
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作者：
NERIISHI, K;FRANK, L
假设新生大鼠在1个月左右对长时间高氧暴露的耐受性正常丧失。的年龄可能与性激素的显着增加发生在这一时期进行了测试。与假手术大鼠相比，20日龄去势雄性大鼠在> 95%O2下暴露于> 45日龄的高O2时，存活率显著增加[去势组，166只中的115只（69%）vs.假手术组，156只中的59只（38%）（P < 0.001）]。替吉奥替代导致的存活率与假手术大鼠相当[30/87（34%）]。在雌性大鼠中未观察到这种保护作用[存活率：卵巢切除术，16/33（48%）vs.假手术，14/28（50%）]。老年去势雄性动物的生存率提高与肺抗氧化酶的增加无关，而肺抗氧化酶的增加通常见于耐O2的新生大鼠。去势确实导致了显著的肺形态学变化，包括显著增大的肺体积（4.54 ± 0.05）。0.72与3.76 .+-相比。0.29 ml/100 g）和末端空气间隙[平均线性截距（LM）= 51.6 . ±. 5.0与46.3 .+-相比。4.1μ m（P < 0.001）]。替吉奥替代也防止了这些形态学变化。肺生长的改变可能与去势后其他内分泌失衡的影响有关，可能是去势雄性大鼠在新生期后相对O2耐受性的重要因素。
The hypothesis that the normal loss of tolerance of neonatal rats to prolonged hyperoxic exposure at around 1 mo. of age might be related to the marked increase in sex hormones occurring around this period was tested. Male rats castrated at 20 days of age demonstrated significantly increased survival in > 95% O2 compared with sham-operated rats when exposed to high O2 at various ages > 45 days [castrated, 115 of 166 (69%) vs. sham, 59 of 156 (38%) (P < 0.001)]. Testosterone replacement led to survival rates comparable with sham-operated rats [30 of 87 (34%)]. No such protective effect was observed in female rats [survival: ovariectomy, 16 of 33 (48%) vs. sham, 14 of 28 (50%)]. The improved survival in the older castrated males was not associated with an increase in lung antioxidant enzymes, which is normally seen in O2-tolerant neonatal rats. Castration did result in marked morphological lung changes, including significantly enlarged lung volumes (4.54 .+-. 0.72 vs. 3.76 .+-. 0.29 ml/100 g) and terminal air spaces [mean linear intercept (LM) = 51.6 .+-. 5.0 vs. 46.3 .+-. 4.1 .mu.m (P < 0.001)]. Testosterone replacement also prevented these morphological changes. The altered lung growth may be related to the influence of other endocrine imbalances after castration and may be an important factor in the relative O2 tolerance of the castrated male rats beyond the neonatal period.