NON-INVASIVE TOMOGRAPHIC STUDY OF CEREBRAL BLOOD-FLOW AND OXYGEN-METABOLISM INVIVO - POTENTIALS, LIMITATIONS, AND CLINICAL-APPLICATIONS IN CEREBRAL ISCHEMIC DISORDERS
NON-INVASIVE TOMOGRAPHIC STUDY OF CEREBRAL BLOOD-FLOW AND OXYGEN-METABOLISM INVIVO - POTENTIALS, LIMITATIONS, AND CLINICAL-APPLICATIONS IN CEREBRAL ISCHEMIC DISORDERS
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DOI：
10.1159/000115247
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发表时间：
1981-01-01
影响因子：
2.4
通讯作者：
CASTAIGNE, P
中科院分区：
文献类型：
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作者：
BARON, JC;BOUSSER, MG;CASTAIGNE, P
C15 O2和15 O2的无创连续吸入技术与正电子发射断层扫描（PET）结合提供被认为代表局部脑血流量（CBF）和氧提取分数（OEF）的脑图像。狒狒的实验研究已经证实，C15 O2吸入允许CBF的断层测量。强调了PET绝对定量中涉及的许多困难，以及15 O吸入模型固有的一些局限性。然而，在正常青年人中获得的局部CBF、OEF和CMRO_2值是令人满意的。近期脑梗死的临床应用已经允许两种相反类型的血流-代谢解偶联被识别，这似乎通常是组织预后的预测。还描述了梗塞内CBF和OEF自发变化的时间过程。此外，我们的研究还揭示了幕上脑梗死中以前未知的“交叉小脑神经联系不能”现象。最后，慢性分水岭缺血状态，可能通过手术血运重建可逆，已被确定为可能参与分水岭坏死的进展。这种方法的临床潜力是相当大的。
The non-invasive continuous inhalation technique of C15O2and15O2coupled with positron emission tomography (PET) provides brain images that are thought to represent local cerebral blood flow (CBF) and oxygen extraction fraction (OEF). Experimental studies in baboons have confirmed that C15O2inhalation allows tomographic measurement of CBF. The numerous difficulties involved in PET absolute quantitation are stressed, as well as some limitations inherent to thel5O inhalation model. However, the values for local CBF, OEF and CMRO2obtained in normal young subjects are satisfactory in view of the above-mentioned limitations. The clinical application to recent cerebral infarction has allowed two opposite types of flow-metabolism uncoupling to be identified, which appear to be often predictive of tissue prognosis. The time course of spontaneous changes in CBF and OEF within the infarct is also described. Our studies have, in addition, revealed the previously unknown phenomenon of ‘crossed cerebellar diaschisis’ in supratentorial infarction. Lastly, a state of chronic watershed ischemia, potentially reversible by surgical revascularization, has been identified as presumably involved in the progression of watershed necrosis. The clinical potentials of this method appear considerable.