Bioactive cassane diterpenoids from the seeds of Caesalpinia sappan
Bioactive cassane diterpenoids from the seeds of Caesalpinia sappan
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DOI：
10.1016/j.phytol.2017.09.007
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发表时间：
2017-12
影响因子：
1.7
通讯作者：
Zhu Nailiang;Xu-dong Xu-Xu-dong-Xu-47158442;M. Hu;Zhonghao Sun;Tong-yu Wu;Jing-quan Yuan;Haifeng Wu;Yu Tian;Pengfei Li;Jun-shan Yang;G. Ma
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文献类型：
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作者：
Zhu Nailiang;Xu-dong Xu-Xu-dong-Xu-47158442;M. Hu;Zhonghao Sun;Tong-yu Wu;Jing-quan Yuan;Haifeng Wu;Yu Tian;Pengfei Li;Jun-shan Yang;G. Ma
从苏木（Caesalpinia sappans）种子的甲醇提取物中分离得到三个新的卡烷型二萜化合物，命名为caesalppans G-I（1-3）和三个已知的二萜化合物（4-6）。它们的结构根据光谱数据确定。其中化合物2显示出中等的抗疟活性，IC 50值为2.4 μM;化合物4显示出中等的抗炎活性，IC 50值为28.65 μM。
Three new cassane-type diterpenoids named caesalppans G-I(1–3)together with three known ones (4–6), were isolated from the methanol extract ofCaesalpinia sappanseeds. Their structures were determined based on spectroscopic data. Among the isolated compounds, compound2displayed a moderate antimalarial activity with an IC50value of 2.4 μM, and compound4showed mild anti-inflammatory activity with an IC50value of 28.65 μM.