The E-Id axis specifies adaptive and innate lymphoid lineage cell fates
The E-Id axis specifies adaptive and innate lymphoid lineage cell fates
复制标题
E-Id 轴指定适应性和先天淋巴谱系细胞的命运
DOI：
10.1093/jb/mvac068
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Miyazaki Kazuko
中科院分区：
文献类型：
--
作者：
Miyazaki Masaki;Miyazaki Kazuko
我们的身体经常受到细菌和病毒等病原体入侵的威胁。针对病原体的免疫反应是在适应性和先天免疫系统的协同作用下引起的。适应性免疫细胞包括T细胞和B细胞，它们通过免疫球蛋白（Ig）和T细胞受体（TCR）等抗原识别受体识别来自病原体的各种抗原，并引起抗原特异性免疫反应以消灭病原体。这种对多种抗原的特异性识别依赖于igandtcr基因的V(D)J DNA重组，这是由Rag（重组激活基因）1/Rag2蛋白复合体产生的。rag1 /2基因的表达在T细胞和B细胞发育过程中受到严格控制；rag1 /2基因的表达表明了对适应性淋巴细胞谱系的承诺。在这篇综述文章中，我们将讨论适应性和先天淋巴样细胞之间的发育分化，转录因子，特别是E和Id蛋白，在谱系承诺中的作用，以及raggene位点的调控。
Our bodies are constantly threatened with the invasion of pathogens, such as bacteria and virus. Immune responses against pathogens are evoked in collaboration with adaptive and innate immune systems. Adaptive immune cells including T and B cells recognize various antigens from pathogens through the antigen recognition receptors such as immunoglobulin (Ig) and T-cell receptor (TCR), and they evoke antigen-specific immune responses to eliminate the pathogens. This specific recognition of a variety of antigens relies on the V(D)J DNA recombination ofIgandTCRgenes, which is generated by the Rag (recombination activation gene) 1/Rag2 protein complex. The expression ofRag1/2genes is stringently controlled during the T and B cell development;Rag1/2gene expression indicates the commitment towards adaptive lymphocyte lineages. In this review article, we will discuss the developmental bifurcation between adaptive and innate lymphoid cells, and the role of transcription factors, especially the E and Id proteins, upon the lineage commitment, and the regulation ofRaggene locus.