A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects
A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects
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DOI：
10.1016/j.diabres.2006.10.005
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发表时间：
2007-07-01
影响因子：
5.1
通讯作者：
Matsuzawa, Yuji
中科院分区：
文献类型：
--
作者：
Matsuhisa, Munehide;Yamasaki, Yoshimitsu;Matsuzawa, Yuji
胰岛素抵抗是葡萄糖耐受不良和2型糖尿病的主要原因，并在这些患者中诱导严重动脉粥样硬化的进展。脂联素是一种脂肪特异性蛋白质，与肥胖和2型糖尿病患者的胰岛素抵抗呈负相关。本研究的目的是评估血清脂联素水平作为胰岛素抵抗的各种状态的胰岛素抵抗的标志物的潜力。此外，我们试图建立一个修正的指数的稳态模型评估指数（HOMA-IR），计算从产品的血清胰岛素和血浆葡萄糖水平除以血清脂联素水平（HOMA-AD），我们招募了117名日本受试者的不同程度的糖耐量和血清脂联素水平和胰岛素敏感性（M值）使用正常血糖高胰岛素钳夹技术。胰岛素抵抗的金标准指数M值与空腹胰岛素（r =-0.313，P < 0.001）、血糖（r =-0.319，P < 0.001）和脂联素（r = 0.241，P < 0.002）水平显著独立相关。M值与HOMA-AD的相关性（r =-0.643，P < 0.001）高于HOMA-IR值（r =-0.591，P < 0.001）。中度高血糖受试者空腹血糖> 8.0 mmol/L（n = 30）时，HOMA-AD与M值的相关性比HOMA-IR更显著（r =-0.535，P = 0.005对r =-0.461，P = 0.010）。因此，我们想提出一种新的指数，HOMA-AD，作为一个简单和适当的指标，用于确定胰岛素抵抗，即使在糖尿病患者明显的高血糖症。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Insulin resistance is the principal cause of glucose intolerance and type 2 diabetes and induces progression of severe atherosclerosis in these patients. Adiponectin, the adipose-specific proteins, is known to correlate negatively with insulin resistance in patients with obesity and type 2 diabetes. The purpose of this study was to evaluate the potential of using serum adiponectin levels as a marker of insulin resistance in various states of insulin resistance. Furthermore, we attempted to establish a modified index of the homeostasis model assessment index (HOMA-IR), calculated from the product of serum insulin and plasma glucose levels divided by serum adiponectin levels (HOMA-AD).We recruited 117 Japanese subjects with various degrees of glucose tolerance and determined serum adiponectin levels and insulin sensitivity (M-value) by using the euglycemic hyperinsulinemic clamp technique. M-value, the gold standard index of insulin resistance, correlates significantly and independently with fasting insulin (r = -0.313, P < 0.001), glucose (r = -0.319, P < 0.001), and adiponectin (r = 0.241, P < 0.002) levels. M-values were more significantly correlated with HOMA-AD (r = -0.643, P < 0.001) than HOMA-IR values (r = -0.591, P < 0.001). In subjects with moderate hyperglycemia (fasting glucose levels > 8.0 mmol/L, n = 30), HOMA-AD showed a more significant correlation with the M-value than HOMA-IR (r = -0.535, P = 0.005 versus r = -0.461, P = 0.010).We would therefore like to propose a novel index, HOMA-AD, as a simple and adequate index for determining insulin resistance even in diabetic patients with overt hyperglycemia. (c) 2006 Elsevier Ireland Ltd. All rights reserved.