Inhibitory effects of fluoroquinolone antibiotics on Babesia divergens and Babesia microti, blood parasites of veterinary and zoonotic importance.
Inhibitory effects of fluoroquinolone antibiotics on Babesia divergens and Babesia microti, blood parasites of veterinary and zoonotic importance.
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DOI：
10.2147/idr.s159519
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发表时间：
2018
影响因子：
3.9
通讯作者：
Igarashi I
中科院分区：
文献类型：
--
作者：
Rizk MA;AbouLaila M;El-Sayed SAE;Guswanto A;Yokoyama N;Igarashi I
本研究旨在评价氟喹诺酮类抗生素恩诺沙星、依诺沙星、曲伐氟沙星、诺氟沙星和氧氟沙星在体外和体内对分歧巴伯螨和田鼠巴伯螨的生长抑制作用。氟喹诺酮类抗生素对B. divergens和B. MicroTi分别使用基于荧光的测定进行评价。此外，在体外培养的B上测试了高效氟喹诺酮类抗生素（恩诺沙星、依诺沙星和曲伐他汀）与醋酸二氮烯、木犀草素或四磷酸咯萘啶的联合治疗。分歧者对B体外生长最有效的氟喹诺酮类药物为恩诺沙星、曲伐沙星和依诺沙星。其次为诺氟沙星和氧氟沙星。此外，依诺沙星或曲伐他汀与醋酸亚胺氮、木犀草素或咯萘啶四磷酸盐的组合显著增强了对B生长的抑制作用。在体外培养中的分歧。感染B. Microti、依诺沙星和醋酸亚胺嗪联合治疗显示出潜在的抗巴贝西虫作用。这些结果表明，安全和廉价的氟喹诺酮类药物，如依诺沙星，可用于治疗临床病例的巴贝虫。在动物或人类身上。
This study aimed to evaluate the inhibitory effects of fluoroquinolone antibiotics, including enrofloxacin, enoxacin, trovafloxacin, norfloxacin, and ofloxacin, on the in vitro and in vivo growth of Babesia divergens and Babesia microti parasites, respectively. The in vitro and in vivo inhibitory effects of fluoroquinolone antibiotics against B. divergens and B. microti, respectively were evaluated using fluorescence-based assay. Additionally, combination therapies of highly effective fluoroquinolone antibiotics (enrofloxacin, enoxacin, and trovafloxacin) with diminazene aceturate, luteolin, or pyronaridine tetraphosphate were tested on the in vitro cultures of B. divergens. Enrofloxacin, trovafloxacin, and enoxacin were the most effective fluoroquinolones against the in vitro growth of B. divergens, followed by norfloxacin and ofloxacin. Furthermore, a combination of enoxacin or trovafloxacin with either diminazene aceturate, luteolin, or pyronaridine tetraphosphate significantly enhanced the inhibitory effect on the growth of B. divergens in in vitro cultures. In mice infected by B. microti, enoxacin and diminazene aceturate combination therapy exhibited a potential antibabesial effect. These results suggest that safe and cheap fluoroquinolone, such as enoxacin, might be used for the treatment of clinical cases caused by Babesia spp. in animals or humans.