Diagnostic implication of fibrin degradation products and D-dimer in aortic dissection.
Diagnostic implication of fibrin degradation products and D-dimer in aortic dissection.
复制标题
纤维蛋白降解产物和 D-二聚体在主动脉夹层中的诊断意义
DOI：
10.1038/srep43957
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发表时间：
2017-03-06
影响因子：
4.6
通讯作者：
Jing Z
中科院分区：
文献类型：
--
作者：
Dong J;Duan X;Feng R;Zhao Z;Feng X;Lu Q;Jing Q;Zhou J;Bao J;Jing Z
纤维蛋白降解产物（FDP）和D-二聚体被认为与许多血管疾病有关。本研究旨在探讨FDP和D-二聚体在主动脉夹层诊断中的意义。收集主动脉夹层患者202例作为病例组，收集其他心血管疾病患者150例作为非夹层组，包括心肌梗死（MI）45例、肺梗死51例、腹主动脉瘤54例，健康体检者27例作为空白对照组。采用免疫散射比浊法检测FDP和D-二聚体水平。采用Logistic回归分析评价FDP和D-二聚体对主动脉夹层患者的影响。采用ROC曲线分析FDP和D-二聚体的诊断价值。主动脉夹层患者血浆FDP和D-二聚体水平显著高于非夹层患者和健康对照组。FDP和D-二聚体均为主动脉夹层的危险因素。ROC曲线分析显示，FDP和D-二聚体对主动脉夹层患者和非夹层患者的诊断价值不高。FDP和D-二聚体的AUC均为0.863，可作为鉴别主动脉夹层患者和健康对照者的有价值的诊断指标。
Fibrin degradation products (FDP) and D-dimer have been considered to be involved in many vascular diseases. In this study we aimed to explore the diagnostic implication of FDP and D-dimer in aortic dissection patients. 202 aortic dissection patients were collected as the case group, 150 patients with other cardiovascular diseases, including myocardial infarction (MI, n = 45), pulmonary infarction (n = 51) and abdominal aortic aneurysm (n = 54) were collected as non-dissection group, and 27 healthy people were in the blank control group. The FDP and D-dimer levels were detected with immune nephelometry. Logist regression analysis was performed to evaluate the influence of FDP and D-dimer for the aortic dissection patients. ROC curve was used to determine the diagnostic value of FDP and D-dimer. The FDP and D-dimer levels were significantly higher in aortic dissection patients than in non-dissection patients and the healthy controls. FDP and D-dimer were both the risk factors for patients with aortic dissection. From the ROC analysis, diagnostic value of FDP and D-dimer were not high to distinguish aortic dissection patients from the non-dissection patients. However FDP and D-dimer could be valuable diagnostic marker to differentiate aortic dissection patients and healthy controls with both AUC 0.863.