Sticky Hydrogels from Hydrazide-Functionalized Poly(oligo(ethylene glycol) methacrylate) and Dialdehyde Cellulose Nanocrystals with Tunable Thermal and Strain-Hardening Characteristics
Sticky Hydrogels from Hydrazide-Functionalized Poly(oligo(ethylene glycol) methacrylate) and Dialdehyde Cellulose Nanocrystals with Tunable Thermal and Strain-Hardening Characteristics
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DOI：
10.1021/acssuschemeng.1c03183
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发表时间：
2021-07-26
影响因子：
8.4
通讯作者：
Tam, Kam C.
中科院分区：
文献类型：
--
作者：
Nasseri, Rasool;Tam, Kam C.
具有可调转变温度和粘附力的热响应可注射水凝胶是需要弱到中等粘附力的生物医学应用的理想选择。通过交联酰肼官能化聚（低聚（乙二醇）甲基丙烯酸酯）（POEGMA-H）与二醛纤维素纳米晶体（DACNC）制备了具有可调转变温度和应变硬化的智能粘性水凝胶，并阐明了其粘合特性。对低于和高于转变温度的水凝胶进行的探针粘性测试表明，由于折叠链不利地暴露于水，在转变温度下应力和粘附功增加。通过增加 OGEMA(300) 单体的百分比，水凝胶在转变温度下表现出应力和粘附功的增加。 POEGMA-H 聚合物中较高比例的 OGEMA(300) 单体可产生较厚的刷子。因此，在变形过程中链条暴露于水的面积增加，导致观察到更高的应力和粘附功。
Thermoresponsive injectable hydrogels with a tunable transition temperature and adhesion are ideal for biomedical applications, where weak to moderate adhesion is required. Smart sticky hydrogels with tunable transition temperature and strain hardening were prepared by cross-linking hydrazide-functionalized poly(oligo(ethylene glycol) methacrylate) (POEGMA-H) with dialdehyde cellulose nanocrystals (DACNC), and their adhesive characteristics were elucidated. Probe-tack tests on hydrogels below and above the transition temperature revealed an increase in the stress and work of adhesion at the transition temperature due to unfavorable exposure of the collapsed chains to water. By increasing the percentage of OGEMA(300) monomer, the hydrogels displayed an increase in the stress and work of adhesion at their transition temperatures. Higher percentages of OGEMA(300) monomer yielded a thicker brush in the POEGMA-H polymer. As a result, the exposed area of the chain to water was enhanced during deformation, leading to the observed higher stress and work of adhesion.