Primary malignant melanoma of the vagina: Long-term remission following radiation therapy
Primary malignant melanoma of the vagina: Long-term remission following radiation therapy
复制标题
DOI：
10.1006/gyno.1998.4982
复制
发表时间：
1998-07-01
影响因子：
4.7
通讯作者：
Vavra, N
中科院分区：
文献类型：
--
作者：
Petru, E;Nagele, F;Vavra, N
Objective.描述原发性阴道黑色素瘤患者的特点和临床过程中接受治疗的三个大型AustrianInstitutes.Methods，14例患者的医疗记录在妇产科的格拉兹和维也纳大学和萨尔茨堡妇女医院1982年和1996年之间进行了审查。诊断时的中位年龄为73岁。所有患者的症状包括阴道出血。肿瘤小于或等于3 cm的7例患者中有3例（43%）存活超过5年，而肿瘤大小>3 cm的7例患者中无1例存活超过5年，接受放疗（除手术切除外或作为主要治疗）的9例患者中有3例（33%）存活超过5年，其他潜在的预后因素如年龄、位置、FIGO分期、浸润深度、Chung水平、组织学、细胞类型、有丝分裂计数、血管受累、溃疡、p53积聚、手术类型、放疗或化疗类型似乎与患者的结局无关。中位总生存期为10个月（1-153个月），5年无瘤生存率为14%，总生存率为21%。3例长期生存者均局部复发。所有3例长期存活的患者的病灶小于或等于3 cm，并接受了原发性放疗（n = 2）或原发性病灶完全切除后的辅助放疗（n = 1），鉴于总体生存率较差，无论治疗如何，对于小于或等于3 cm的阴道原发性恶性黑色素瘤患者，放射治疗可能是一种有价值的有限替代或辅助手术直径，（C）1998年学术出版社。
Objective. To describe the characteristics and clinical course of patients with primary vaginal melanoma treated at three large Austrian institutions.Methods, The medical records of 14 patients treated at the Departments of Obstetrics and Gynecology of the Universities of Graz and Vienna and the Salzburg Women's Hospital between 1982 and 1996 were reviewed.Results. The median age at diagnosis was 73 years. Presenting symptoms included vaginal bleeding in all patients. Three of seven patients (43%) with tumors less than or equal to 3 cm survived longer than 5 years compared to none of seven patients with a tumor size >3 cm, Three of nine patients (33%) who received radiotherapy either in addition to surgical excision or as primary treatment, survived for 5 years, Other potential prognostic factors such as age, location, FIGO stage, depth of invasion, Chung level, histology, cell type, mitotic count, vessel involvement, ulceration, p53 accumulation, type of surgery, type of radiotherapy, or chemotherapy did not seem to correlate with the patients' outcome. The median overall survival was 10 months (range 1-153), The 5-year disease-free and overall survival rates were 14 and 21%, respectively. All three long-term survivors recurred locally.Conclusion. All three patients who had long-term survival had lesions less than or equal to 3 cm and received either primary radiotherapy (n = 2) or adjuvant radiotherapy after complete excision of the primary lesion (n = 1), In view of the poor overall survival rates, regardless of treatment, radiotherapy may be a limited valuable alternative or adjunct to surgery in patients with primary malignant melanoma of the vagina less than or equal to 3 cm in diameter, (C) 1998 Academic Press.