Essential tremor: Mild olfactory dysfunction in a cerebellar disorder
Essential tremor: Mild olfactory dysfunction in a cerebellar disorder
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DOI：
10.1016/j.parkreldis.2005.03.003
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发表时间：
2005-01-01
影响因子：
4.1
通讯作者：
Louis, ED
中科院分区：
文献类型：
--
作者：
Applegate, LM;Louis, ED
据报道，小脑疾病患者会出现嗅觉功能障碍，包括退行性共济失调和特发性震颤 (ET)。以前的研究没有考虑 ET 中可能发生的轻度认知缺陷的影响，并且可以解释 ET 病例中嗅觉测试分数较低的原因。我们将初始样本数量增加了一倍多（37 个 ET 病例和 37 个对照）[Louis ED, Bromley SM, Jurewicz EC, Watner D. 原发性震颤中的嗅觉功能障碍：与疾病持续时间或严重程度无关的缺陷。神经病学 2002；59：1631-3。 [1]]并对简易精神状态测试分数进行了调整。在对简单精神状态测试分数和其他潜在混杂因素进行调整后，宾夕法尼亚大学气味识别测试分数在 87 名 ET 病例中仍然低于 92 名对照组（p=0.04）。这些发现表明，ET 患者的嗅觉功能障碍与轻度认知缺陷无关，并支持最近的研究，即小脑可能在中枢嗅觉处理中发挥作用。 (c) 2005 Elsevier Ltd. 保留所有权利。
Olfactory dysfunction has been reported to occur in patients with cerebellar disorders, including degenerative ataxias and essential tremor (ET). Previous studies ha, e not considered the effects of mild cognitive deficits, which can occur in ET, and could explain the lower olfaction test scores in ET cases. We more than doubled our initial sample (37 ET cases and 37 controls) [Louis ED, Bromley SM, Jurewicz EC, Watner D. Olfactory dysfunction in essential tremor: a deficit unrelated to disease duration or severity. Neurology 2002;59:1631-3. [1]] and made adjustments for the mini mental status test score. The University of Pennsylvania Smell Identification Test score remained lower in 87 ET cases compared to 92 controls after adjustment for mini mental status test score and other potential confounders (p=0.04). These findings: suggest that olfactory dysfunction in ET patients occurs independently of mild cognitive deficits and support recent work that the cerebellum may play a role in central olfactory processing. (c) 2005 Elsevier Ltd. All rights reserved.