MGUS bone
MGUS bone
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MGUS骨
DOI：
10.1093/omcr/omz082
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发表时间：
2019
影响因子：
0.5
通讯作者：
Uemura Makiko
中科院分区：
文献类型：
--
作者：
Imataki Osamu;Uemura Makiko
一位65岁男性因颈椎后纵韧带严重骨化而转介至本院接受骨科手术。计算机断层扫描显示他的骨盆有一个巨大的溶骨性病变。其他筛查检查包括骨密度和骨质疏松生物标志物检测、骨密度图和18F-氟脱氧葡萄糖-正电子发射断层扫描均正常。骨髓穿刺显示浆细胞轻微增加，为3.8%。这些发现导致诊断为单克隆丙种球蛋白病，但意义不明（MGUS）。在多发性骨髓瘤发作或发生之前，与MGUS相关的结构性溶骨性骨（无明显骨矿物质代谢异常）可能是常见的。
A 65-year-old man was referred to our hospital to undergo orthopedic surgery due to severe cervical ossification of the posterior longitudinal ligament. Computed tomography scanning showed a massive osteolytic lesion in his pelvis. Other screening examinations including detection of bone mineral density and osteoporosis biomarkers, bone scintigram and18F-fluorodeoxyglucose-positron emission tomography were all normal. Bone marrow aspiration revealed slightly increased plasmacytes at 3.8%. These findings led to a diagnosis of monoclonal gammopathy with undetermined significance (MGUS). Architectural osteolytic bone associated with MGUS without apparent abnormality in bone mineral metabolism could be a common occurrence prior to onset or occurrence of multiple myeloma.