Brain activities associated with gaming urge of online gaming addiction
Brain activities associated with gaming urge of online gaming addiction
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DOI：
10.1016/j.jpsychires.2008.09.012
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发表时间：
2009-04-01
影响因子：
4.8
通讯作者：
Chen, Cheng-Sheng
中科院分区：
文献类型：
--
作者：
Ko, Chih-Hung;Liu, Gin-Chung;Chen, Cheng-Sheng
这项研究的目的是通过评估与提示引起的游戏冲动相关的大脑区域来确定在线游戏成瘾的神经基础。对 10 名有网络游戏成瘾的参与者和 10 名没有网络游戏成瘾的对照对象进行了测试。他们在接受功能性磁共振成像（fMRI）扫描时，会看到游戏图片和配对的马赛克图片。使用SPM2软件计算观看游戏图片和观看马赛克图片时血氧水平依赖（BOLD）信号的对比度，以评估大脑激活情况。与对照组相比，成瘾组的右眶额皮质、右伏隔核、双侧前扣带皮层和内侧额叶皮质、右背外侧前额叶皮质和右尾状核被激活。由上述大脑区域定义的感兴趣区域（ROI）的激活与自我报告的游戏冲动和由WOW图片引起的游戏体验回忆呈正相关。结果表明，在线游戏成瘾中线索诱导的游戏冲动/渴望的神经基质与物质依赖中线索诱导的渴望的神经基质相似。据报道，上述大脑区域会导致物质依赖的渴望，在这里我们表明，相同的区域也参与了在线游戏的冲动/渴望。因此，结果表明，在线游戏成瘾中的游戏冲动/渴望和物质依赖中的渴望可能具有相同的神经生物学机制。 (C) 2008 Elsevier Ltd. 保留所有权利。
The aim of this study was to identify the neural substrates of online gaming addiction through evaluation of the brain areas associated with the cue-induced gaming urge. Ten participants with online gaming addiction and 10 control subjects without online gaming addiction were tested. They were presented with gaming pictures and the paired mosaic pictures while undergoing functional magnetic resonance imaging (fMRI) scanning. The contrast in blood-oxygen-level dependent (BOLD) signals when viewing gaming pictures and when viewing mosaic pictures was calculated with the SPM2 software to evaluate the brain activations. Right orbitofrontal cortex, right nucleus accumbens, bilateral anterior cingulate and medial frontal cortex, right dorsolateral prefrontal cortex, and right caudate nucleus were activated in the addicted group in contrast to the control group. The activation of the region-of-interest (ROI) defined by the above brain areas was positively correlated with self-reported gaming urge and recalling of gaming experience provoked by the WOW pictures. The results demonstrate that the neural substrate of cue-induced gaming urge/craving in online gaming addiction is similar to that of the cue-induced craving in substance dependence. The above-mentioned brain regions have been reported to contribute to the craving in substance dependence, and here we show that the same areas were involved in online gaming urge/craving. Thus, the results suggest that the gaming urge/craving in online gaming addiction and craving in substance dependence might share the same neurobiological mechanism. (C) 2008 Elsevier Ltd. All rights reserved.