THE SPERMICIDE NONOXYNOL-9 DOES NOT INACTIVATE PAPILLOMAVIRUS
THE SPERMICIDE NONOXYNOL-9 DOES NOT INACTIVATE PAPILLOMAVIRUS
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DOI：
10.1097/00007435-199207000-00004
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发表时间：
1992-07-01
影响因子：
3.1
通讯作者：
SHAH, KV
中科院分区：
文献类型：
--
作者：
HERMONAT, PL;DANIEL, RW;SHAH, KV
阴道杀精剂是有效的避孕药，并且还能够通过其对细菌细胞膜和病毒包膜的去污作用来灭活许多性传播病原体。测试了 5% 浓度的 nonoxynol-9（杀精剂最常用的活性成分）其降低 1 型牛乳头瘤病毒 (BPV-1) 转化活性以及 BK 病毒 (BKV) 和巨细胞病毒 (CMV) 感染性的能力。 Nonoxynol-9显着降低了CMV（一种包膜病毒）的感染性，但没有显着影响非包膜病毒BPV-1和BKV的活性。乳头瘤病毒感染与宫颈癌的病因密切相关。据报道，阴道杀精剂对宫颈癌的保护作用很可能不是通过杀精剂直接灭活乳头瘤病毒来介导的。
Vaginal spermicides are effective contraceptives, and are also capable of inactivating many sexually transmitted pathogens by their detergent effect on bacterial cell membranes and viral envelopes. A 5% concentration of nonoxynol-9, the most frequently used active ingredient of spermicides, was tested for its ability to reduce the transforming activity of bovine papillomavirus type 1 (BPV-1), and the infectivity of BK virus (BKV) and cytomegalovirus (CMV). Nonoxynol-9 markedly reduced the infectivity of CMV, an enveloped virus, but did not significantly affect the activity of the nonenveloped viruses BPV-1 and BKV. Papillomavirus infections are strongly implicated in the etiology of cervical cancer. 'the reported protective effect of vaginal spermicides against cervical cancer is very likely not mediated by direct inactivation of papillomaviruses by the spermicide.