Effect of interleukin-11 on body temperature in afebrile and febrile rats.
Effect of interleukin-11 on body temperature in afebrile and febrile rats.
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白细胞介素11对无发热和发热大鼠体温的影响。
DOI：
10.1159/000026446
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发表时间：
2000
影响因子：
2.4
通讯作者：
Kluger,MJ
中科院分区：
文献类型：
--
作者：
Gourine,AV;Rudolph,K;Leon,LR;Kluger,MJ
白细胞介素（IL）-11是细胞因子gp 130家族的成员。与IL-6（另一种gp 130细胞因子）相反，IL-11不会诱导人体发热。本研究观察了侧脑室注射重组人白细胞介素-11（hrIL-11）对发热和非发热大鼠体温的影响。结果表明：（i）脑室注射5、50和500 ng hrIL-11不改变大鼠体温;在脑室注射500 ng hrIL-11的大鼠中，大肠杆菌内毒素（50 μg/kg）的启动更快，（iii）hrIL-11诱导的发热初始阶段的增强并不伴随着IL-6和肿瘤坏死因子（TNF）血浆浓度的变化。这些结果表明，hrIL-11在脑室给药时无热原。所获得的数据还表明，中央应用的hrIL-11改变体温的热原刺激的条件下，但这种影响是不是由于IL-6或TNF的血浆浓度的变化。这些数据表明，在全身炎症反应的发展过程中，gp 130亚基的激活在改变体温方面变得有效。
Interleukin (IL)-11 is a member of the gp130 family of cytokines. In contrast to IL-6 (another gp130 cytokine), IL-11 does not induce fever in humans. In the present study, the effect of recombinant human IL-11 (hrIL-11) injected intracerebroventricularly on body temperature of afebrile and febrile rats was studied. Results showed that: (i) hrIL-11 in doses of 5, 50 and 500 ng injected into the cerebral ventricles does not alter body temperature in rats; (ii) febrile response induced by intraperitoneal injection ofE. coliendotoxin (50 µg/kg) was initiated more rapidly in rats injected with 500 ng of hrIL-11 in the cerebral ventricles, and (iii) the enhancement of the initial phase of fever induced by hrIL-11 was not accompanied by changes in plasma concentrations of IL-6 and tumor necrosis factor (TNF). These results indicate that hrIL-11 is not pyrogenic when administered into the brain ventricles. The data obtained also demonstrate that central application of hrIL-11 alters body temperature in conditions of pyrogenic stimulation, but that this effect is not due to the alterations in plasma concentrations of IL-6 or TNF. These data suggest that during the development of the systemic inflammatory response, activation of gp130 subunit becomes effective in altering body temperature.