Clinical value of enzyme immunoassay that detects rubella-specific immunoglobulin M immediately after disease onset
Clinical value of enzyme immunoassay that detects rubella-specific immunoglobulin M immediately after disease onset
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发病后立即检测风疹特异性免疫球蛋白 M 的酶联免疫分析的临床价值
DOI：
10.1111/1348-0421.12664
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Komano J.
中科院分区：
文献类型：
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作者：
Kurata T;Uchino K;Hotta C;Ogura A;Miyoshi T;Ogawa T;Kanbayashi D;Tanaka T;Yumisashi T;Komano J.
共有300例经核酸检测确诊的风疹患者（大部分为成人）接受了研究，以确定使用EIA试剂盒进行风疹特异性IgM检测的临床价值。IgM滴度在皮疹发作后增加，中位IgM滴度在发作后3天显著高于前几天（P< 0.0001）。同样，发病后3天的IgM阳性率（61.5%）显著高于前几天（P< 0.0001）。发病后3天或更长时间针对风疹的IgM检测提供了临床相关信息。
A total of 300 patients with nucleic acid test‐confirmed rubella, mostly adults, were investigated to determine the clinical value of a rubella‐specific IgM test using an EIA kit. IgM titers increased after rash onset, the median IgM titer being significantly higher 3 days post‐onset than on previous days (P< 0.0001). Similarly, the IgM‐positive rate at 3 days post‐onset (61.5%) was significantly higher than on previous days (P< 0.0001). This IgM test against rubella at 3 days or more post‐disease onset provides the clinically relevant information.