Comparison of Serum Albumin, Serum C-Reactive Protein, and Pulse Wave Velocity as Predictors of the 4-Year Mortality of Chronic Hemodialysis Patients
Comparison of Serum Albumin, Serum C-Reactive Protein, and Pulse Wave Velocity as Predictors of the 4-Year Mortality of Chronic Hemodialysis Patients
复制标题
DOI：
10.5551/jat.10397
复制
发表时间：
2011-01-01
影响因子：
4.4
通讯作者：
Nitta, Kosaku
中科院分区：
文献类型：
--
作者：
Amemiya, Nobuyuki;Ogawa, Tetsuya;Nitta, Kosaku
目的：虽然已知血清白蛋白、C反应蛋白（CRP）水平和脉搏波速度（PWV）与血液透析（HD）患者的临床结局相关，但尚不清楚这些参数中哪一个更能预测此类患者的长期死亡率。我们测量了202例接受维持性HD治疗的患者的生化参数，包括血清白蛋白和CRP，以及PWV，并对其进行了4年的随访，其中186名患者被纳入当前的研究分析。我们根据血清白蛋白和CRP水平以及PWV值将186例患者分为三个三分位数，并进行多变量分析以检查三分位数对4年死亡率的影响。二十三（12.4%）例患者在随访期间死亡，死亡组血清白蛋白明显低于存活组，而死亡组的CRP水平和PWV明显高于对照组。Kaplan-Meier分析的结果显示，高CRP的HD患者的全因死亡率的风险显着较高的考克斯比例风险分析的结果的基础上，然而，血清白蛋白和PWV值与全因mortals.Conclusion：这项研究的结果表明，血清CRP水平是一个更好的预测慢性HD患者的死亡率比血清白蛋白或PWV值。
Aim: Although serum albumin and C-reactive protein (CRP) levels and pulse wave velocity (PWV) are known to be associated with the clinical outcome of hemodialysis (HD) patients, it is unknown which of these parameters are more predictive of the long-term mortality of such patients.Methods: We measured biochemical parameters, including serum albumin and CRP, and the PWV of 202 patients on maintenance HD therapy and followed their course for 4 years, and 186 of the patients were enrolled in the current study analyses. We divided the 186 patients into three tertiles according to their serum albumin and CRP levels and PWV values, and conducted multivariate analyses to examine the impact of the tertiles on 4-year mortality.Results: Twenty-three (12.4%) patients died during the follow-up period, and the serum albumin of the group that died was significantly lower than in the group that survived, but the CRP levels and PWV were significantly higher in the group that died. The results of Kaplan-Meier analyses revealed a significantly higher risk of all-cause mortality in HD patients with higher CRP based on the results of Cox proportional hazards analyses; however, the serum albumin and PWV values were not associated with all-cause mortality.Conclusion: The results of this study suggest that serum CRP levels are a better mortality predictor than serum albumin or PWV values of chronic HD patients.