PROPOSAL FOR STANDARDIZED CRITERIA FOR THE DIAGNOSIS OF BENIGN, BORDERLINE, AND MALIGNANT HEPATOCELLULAR LESIONS ARISING IN CHRONIC ADVANCED LIVER-DISEASE
PROPOSAL FOR STANDARDIZED CRITERIA FOR THE DIAGNOSIS OF BENIGN, BORDERLINE, AND MALIGNANT HEPATOCELLULAR LESIONS ARISING IN CHRONIC ADVANCED LIVER-DISEASE
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DOI：
10.1097/00000478-199311000-00004
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发表时间：
1993-11-01
影响因子：
5.6
通讯作者：
NAKANUMA, Y
中科院分区：
文献类型：
--
作者：
FERRELL, LD;CRAWFORD, JM;NAKANUMA, Y
尽管目前的文献包含许多假定的癌前肝细胞增殖和小肝细胞癌的病例，但尚未提出一致的命名法和诊断标准来描述它们。这些结节通过放射照相技术在肝硬化肝脏中检测到，并在移植过程中被切除，代表了肝脏病理学的一种新的、具有挑战性的组织学谱。在这项研究中，由五名肝脏病理学家组成的跨国小组审查了 23 个此类结节，并就诊断标准达成了共识，并设计了描述组织学病变的标准命名法。我们建议将与肝硬化结节几乎没有组织学差异的良性结节分类为再生结节或宏观再生结节，将具有不典型特征且不能诊断为癌的结节分类为交界性结节。这种标准化应有助于进一步研究这些病变的病理特征和临床行为。
Although current literature contains many cases of putative premalignant hepatocellular proliferations and small hepatocellular carcinomas, no consistent nomenclature and diagnostic criteria have been put forward to describe them. These nodules, which are being detected by radiographic techniques in cirrhotic livers and removed during transplantation procedures, represent a new and challenging histologic spectrum of liver pathology. In this study, a multinational panel of five liver pathologists reviewed 23 such nodules and were able to reach a consensus on the diagnostic criteria and to devise a standard nomenclature to describe the histologic lesions. We recommend that benign nodules showing little histologic difference from cirrhotic nodules be classified as regenerative or macroregenerative, and nodules with atypical features not diagnostic of carcinoma be classified as borderline. Such standardization should facilitate further study of the pathologic features and clinical behavior of these lesions.