Multiple subependymal pseudocysts in neonates play a role in later attention deficit hyperactivity and autistic spectrum disorder
Multiple subependymal pseudocysts in neonates play a role in later attention deficit hyperactivity and autistic spectrum disorder
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DOI：
10.1016/j.jfma.2018.08.007
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发表时间：
2019-03-01
影响因子：
3.2
通讯作者：
Tsai, Min-Lan
中科院分区：
文献类型：
--
作者：
Chang, Hsi;Tsai, Chung-Min;Tsai, Min-Lan
背景/目的：评估在新生儿健康检查中意外发现室管膜下假性囊肿、额角囊肿或脉络丛囊肿的正常足月新生儿的长期神经发育结局。方法：2002年至2012年，5569名新生儿出生后第一周接受头颅超声检查。其中，5147名婴儿符合纳入标准。收集数据时，参与者的年龄在5岁到15岁之间。采用单因素方差分析、卡方检验、Yate‘s校正和优势比等统计方法对这些数据进行统计分析。结果：SECS的存在与发育迟缓和发育障碍密切相关，特别是与注意缺陷多动障碍(ADHD)和自闭症谱系障碍(ASD)的关系更为显著。在有多个间隔的参与者中，ADHD或ASD的风险显著增加，其中ADHD和ASD的优势比分别为6.5(95%可信区间=2.27~18.64)和28.54(95%CI=5.98~136.36)，高于总体研究人群。结论：我们的数据显示，正常足月新生儿多个间隔是神经行为结局的危险因素，尤其是在ADHD和ASD。同时，证实了CUS检查作为新生儿健康检查项目的实用性。版权所有(C)2018，台湾医学会。爱思唯尔台湾有限责任公司出版。
Background/purpose: To assess the long-term neurodevelopmental outcome of normal-term neonates who were accidentally found to exhibit subependymal pseudocysts (SEPCs), frontal horn cysts, or choroid plexus cysts through cranial ultrasound (CUS) examination in a neonatal health examination.Methods: In total, 5569 neonates received CUS examination as an item in a health examination during the first week of birth between 2002 and 2012. Among them, 5147 infants fulfilled the inclusion criteria. The participants were aged between 5 and 15 years at the time when the data were collected. We retrospectively collected these data and interpreted their statistical significance by using one-way analysis of variance, Chi-square test with Yate's correction and odds ratios.Results: The presence of SEPCs was significantly correlated with developmental delay and developmental disability, particularly with attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). The risk of ADHD or ASD was significantly higher in participants with multiple SEPCs, among whom the odds ratios for ADHD and ASD were 6.50 (95% confidence interval [CI] = 2.27-18.64) and 28.54 (95% CI = 5.98-136.36), respectively, higher than those for the total study population.Conclusion: Our data revealed multiple SEPCs in normal-term neonates as a risk factor for neurobehavioral outcome, particularly in ADHD and ASD. Simultaneously, the utility of CUS examination as a health examination item for neonates was confirmed. Copyright (C) 2018, Formosan Medical Association. Published by Elsevier Taiwan LLC.