Understanding sarcopenia as a geriatric syndrome
Understanding sarcopenia as a geriatric syndrome
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DOI：
10.1097/mco.0b013e328333c1c1
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发表时间：
2010-01-01
影响因子：
3.1
通讯作者：
Michel, Jean-Pierre
中科院分区：
文献类型：
--
作者：
Cruz-Jentoft, Alfonso J.;Landi, Francesco;Michel, Jean-Pierre
肌少症在65岁以上的人群中非常普遍，导致预后不良（功能下降及其相关后果），对其病理生理学的清晰认识或精确的临床或生物学标记都没有好处。最近的发现“老年综合征”的新的科学定义要求作者回顾当前的肌肉减少症文献，使他们能够确认肌肉减少症不能被认为是一种与年龄相关的疾病，而是一种真正的“老年综合征”。80岁以上的人口中有50%以上患有这种疾病，这与多种原因有关：衰老过程本身、遗传易感性、某些生活习惯、生活条件的变化和一些慢性疾病。此外，肌肉减少症倾向于不良后果，如行动障碍、残疾、生活质量差和死亡。将骨骼肌减少症视为一种老年综合征，使我们能够要求认识并评估其多重危险因素，实施临床和公共卫生方法来管理骨骼肌减少症患者和高危人群，并阐明骨骼肌减少症与虚弱、残疾和死亡之间的联系。
Purpose of reviewHighly prevalent in the population older than 65 years and leading to poor outcomes (functional decline and its related consequences), sarcopenia does not benefit yet either of a clear understanding of its pathophysiology or of precise clinical or biological markers allowing its identification.Recent findingsThe new scientific definition of 'geriatric syndromes' challenges the authors to review the current sarcopenia literature, allowing them to affirm that sarcopenia cannot be considered as an age-related disease but as a true 'geriatric syndrome'. More than 50% of the population older than 80 years suffer from this medical condition, which is linked to multiple causations: the ageing process itself, genetic susceptibility, certain life habits, changes in living conditions and a number of chronic diseases. Moreover, sarcopenia favours poor outcomes such as mobility disorders, disability, poor quality of life and death.SummaryConsidering sarcopenia as a geriatric syndrome allows us to request its recognition and assess its multiple risk factors, to implement a clinical and public health approach to the management of sarcopenic patients and population at risk and to disentangle the links among sarcopenia, frailty, disability and mortality.