Folate-metabolizing gene variants and pregnancy outcome of IVF
Folate-metabolizing gene variants and pregnancy outcome of IVF
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DOI：
10.1016/j.rbmo.2011.03.002
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发表时间：
2011-06-01
影响因子：
4
通讯作者：
Salumets, A.
中科院分区：
文献类型：
--
作者：
Laanpere, M.;Altmaee, S.;Salumets, A.
越来越多的证据表明，叶酸的状态和叶酸代谢基因的变异与女性生殖功能有关。本研究评估了母血叶酸、维生素B-12、同型半胱氨酸和10种叶酸途径基因变异对IVF结局的影响。此外，这些多态性的患病率进行了比较，在439名女性IVF患者和225名生育对照。MTHFR 677 CT杂合子具有较高的优质胚胎比例和较高的妊娠机会。MTHFR 1793 GA杂合性与先前失败的IVF治疗百分比较低相关。FOLR 1 1816 C/delC和1841 G/A杂合性与妊娠丢失风险增加相关。CTH 1208 GT基因型与妊娠机会增加和先前失败的IVF周期数量较少相关，并且与生育对照组相比，具有三次或三次以上先前失败的IVF治疗的IVF患者的基因型频率较低。SLC 19 A1 80 GA杂合子具有减少的先前失败的IVF治疗的数量，并且在可育对照中更普遍。总之，叶酸代谢基因的多态性可能会影响卵巢刺激和IVF的妊娠结局，杂合子个体，而不是野生型纯合子，似乎有更有利的结果。(C)2011年，爱思唯尔有限公司出版的生殖保健有限公司。版权所有。
There is growing evidence that folate status and variation in folate-metabolizing genes are involved in female reproductive functions. This study evaluated the influence of maternal blood folate, vitamin B-12, homocysteine and 10 folate pathway gene variants on IVF outcome. Also, the prevalence of these polymorphisms was compared in 439 female IVF patients and 225 fertile controls. MTHFR 677 CT heterozygotes had a higher proportion of good-quality embryos and an increased chance of pregnancy. MTHFR 1793 GA heterozygosity was associated with a lower percentage of previously failed IVF treatments. Heterozygosity for FOLR1 1816 C/delC and 1841 G/A was associated with a raised risk of pregnancy loss. The CTH 1208 GT genotype was associated with an increased chance of pregnancy and a smaller number of previously failed IVF cycles and the genotype frequency was lower in IVF patients with three or more previously failed IVF treatments compared with fertile controls. SLC19A1 80 GA heterozygotes had a decreased number of previously failed IVF treatments and were more prevalent among fertile controls. In conclusion, polymorphisms in folate-metabolizing genes may affect ovarian stimulation and pregnancy outcome of IVF, and heterozygous individuals, rather than the wild-type homozygotes, appeared to have more favourable outcomes. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.