Responsiveness of subcutaneous human glioma xenografts to various antitumor agents.
Responsiveness of subcutaneous human glioma xenografts to various antitumor agents.
复制标题
皮下人神经胶质瘤异种移植物对各种抗肿瘤药物的反应性。
作者：
Koji Maruo;Yoshito Ueyama;Makoto Inaba;R. Emura;Yasuyuki Ohnishi;Osamu Nakamura;O. Sato;T. Nomura
通过皮下注射系统研究了七种人类神经胶质瘤异种移植物对七种抗肿瘤药物的反应性，并根据反应率评估了这些药物对抗人类神经胶质瘤的功效。使用最大耐受剂量时，尼莫司汀（ACNU）、长春新碱（VCR）、阿霉素（ADR）和长春碱（VLB）的实验缓解率高达86-100%，丝裂霉素（MMC）的实验缓解率为57%，5-氟尿嘧啶（5-FU）和甲氨蝶呤（MTX）的实验缓解率为0%。另一方面，当采用药代动力学与其临床剂量相当的剂量时，ADR的缓解率最高，其次是VCR和ACNU。这些结果表明神经胶质瘤对该皮下注射系统中的各种抗肿瘤药物有显着的反应。
Responsiveness of seven human glioma xenografts to seven antitumor agents was investigated by an sc-iv system and the efficacies of these agents against human glioma were evaluated in terms of response rate. When their maximum tolerated doses were used, experimental response rates of nimustine (ACNU), vincristine (VCR), adriamycin (ADR) and vinblastine (VLB) were as high as 86-100%, while that of mitomycin (MMC) was 57%, and those of 5-fluorouracil (5-FU) and methotrexate (MTX) were 0%. On the other hand, when the doses pharmacokinetically equivalent to their clinical doses were employed, the response rate of ADR was the highest, followed by VCR and ACNU in this order. These results suggest that gliomas are significantly responsive to various antitumor agents in this sc-iv system.