PREPARATION AND APPLICATION OF MAGNETIC POLYMERS FOR TARGETING OF DRUGS
PREPARATION AND APPLICATION OF MAGNETIC POLYMERS FOR TARGETING OF DRUGS
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DOI：
10.1016/0014-5793(79)80940-0
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发表时间：
1979-01-01
期刊：
影响因子：
3.5
通讯作者：
SCHRODER, U
中科院分区：
文献类型：
--
作者：
MOSBACH, K;SCHRODER, U
在过去的几年中，在药物靶向领域中已经引起了相当大的兴趣，因为已经变得清楚的是，为了实现药理学试剂与非靶位点相互作用的最佳作用条件，应该考虑[1]在这种情况下，将抗肿瘤药物与抗体复合的研究是值得注意的[2]同时，脂质体作为载体的应用值得一提，因为它们主要转运到肝脏和脾脏[1]。我们突然想到，磁性材料也可以用作药物的载体，这些药物可以在磁场的帮助下被带到靶部位[4]。这样的特定位置将允许使用高浓度的药物
There hds been constderable interest during the last few years m the area of drug targeting as it has become clear that m order to achieve optimal condrtrons for the action of pharmacologtcdl agents mteraction with non-target sites should be mmunrzed [l] Investrgdtrons to complex antrtumour drugs with antibodies are noteworthy m this context [2] Smularly, the use of hposomes as carrters deserves mention as they are predommantly transported mto the liver and spleen [1]While studying the use of magnetic carriers in affimty chromatography [3] rt occurred to us that magnetrc material might dlso be used as support for drugs which could be brought to the target site wrth the aid of a magnetic field [4] Apart from mmlmrzmg mteractrons with non-target sites such a specific location would allow a high concentration of the drug to be used and would extend the time of exposure at the site