Augmenting the unified protocol for transdiagnostic treatment of emotional disorders with transcranial direct current stimulation in individuals with generalized anxiety disorder and comorbid depression: A randomized controlled trial
Augmenting the unified protocol for transdiagnostic treatment of emotional disorders with transcranial direct current stimulation in individuals with generalized anxiety disorder and comorbid depression: A randomized controlled trial
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DOI：
10.1016/j.jad.2019.11.064
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发表时间：
2020-02-01
影响因子：
6.6
通讯作者：
Ellard, Kristen K.
中科院分区：
文献类型：
--
作者：
Nasiri, Farzad;Mashhadi, Ali;Ellard, Kristen K.
背景：本研究的目的是比较有和没有经颅直流电刺激（tDCS）的情绪障碍跨诊断治疗统一方案（UP）对患有广泛性焦虑障碍（GAD）和共病抑郁症的个体。方法：共有43名被诊断为广泛性焦虑症和共病抑郁症的患者参加了一项随机对照试验（IRCT20140929019334N1）。参与者被随机分为三组，包括UP + tDCS (UP + tDCS, n = 15)，单独UP （UP, n = 13）或等候名单对照组（n = 15）。在基线、治疗后和3个月随访时评估广泛性焦虑症和抑郁症状、担忧严重程度、焦虑敏感性和对不确定性的不耐受。结果：与治疗后和3个月随访时的等候名单对照相比，UP + tDCS治疗和单独UP治疗导致所有测量指标的评分显著降低（所有p值）
Background: The aim of the current study was to compare the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) with and without transcranial direct current stimulation (tDCS) in individuals suffering from generalized anxiety disorder (GAD) and comorbid depression.Methods: A total of 43 individuals diagnosed with GAD and comorbid depression enrolled in a randomized controlled trial (IRCT20140929019334N1). Participants were randomly assigned to three groups including UP with tDCS (UP + tDCS; n = 15), UP alone (UP; n = 13) or wait-list control (n = 15). GAD and depression symptoms, worry severity, anxiety sensitivity, and intolerance of uncertainty were assessed at baseline, post-treatment and 3-month follow-up.Results: Treatment with both UP + tDCS and UP alone resulted in significant lower ratings across all measures relative to wait-list controls at post-treatment and 3-month follow-up (all p-values