Similar network activity from disparate circuit parameters
Similar network activity from disparate circuit parameters
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DOI：
10.1038/nn1352
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发表时间：
2004-12-01
影响因子：
25
通讯作者：
Marder, E
中科院分区：
文献类型：
--
作者：
Prinz, AA;Bucher, D;Marder, E
通常认为，细胞和突触特性需要被调节到特定的值，以允许神经元网络正常工作。为了确定神经元特性和突触强度需要调整到何种程度才能产生给定的网络输出，我们使用突触强度和神经元特性的不同组合模拟了甲壳动物口胃神经节幽门网络的三细胞模型的2000多万个版本。我们发现，几乎无法区分的网络活动可能产生于广泛不同的基础机制，这表明可能有相当大的动物之间的变异性，在许多参数控制网络活动，突触强度和内在膜特性的许多不同的组合可以与适当的网络性能是一致的。
It is often assumed that cellular and synaptic properties need to be regulated to specific values to allow a neuronal network to function properly. To determine how tightly neuronal properties and synaptic strengths need to be tuned to produce a given network output, we simulated more than 20 million versions of a three-cell model of the pyloric network of the crustacean stomatogastric ganglion using different combinations of synapse strengths and neuron properties. We found that virtually indistinguishable network activity can arise from widely disparate sets of underlying mechanisms, suggesting that there could be considerable animal-to-animal variability in many of the parameters that control network activity, and that many different combinations of synaptic strengths and intrinsic membrane properties can be consistent with appropriate network performance.