Diet-induced obesity and weight loss alter bile acid concentrations and bile acid-sensitive gene expression in insulin target tissues of C57BL/6J mice
Diet-induced obesity and weight loss alter bile acid concentrations and bile acid-sensitive gene expression in insulin target tissues of C57BL/6J mice
复制标题
DOI：
10.1016/j.nutres.2017.07.006
复制
发表时间：
2017-10-01
影响因子：
4.5
通讯作者：
Newman, John W.
中科院分区：
文献类型：
--
作者：
La Frano, Michael R.;Hernandez-Carretero, Angelina;Newman, John W.
胆汁酸（BAs）影响葡萄糖、脂质和能量消耗的代谢。我们假设BA浓度和相关基因表达在瘦（低脂饮食）组和饮食诱导肥胖（高脂饮食）组的小鼠中会发生改变，并且在HFD组切换到LFD组减肥后，一些检测到的变化仍会存在。牛磺酸偶联物在肝脏、附睾白色脂肪组织（eWAT）和下丘脑的胆汁酸组成中占主导地位，下丘脑的胆汁酸含量较低（分别接近95%、95%和80%）
Bile acids (BAs) influence the metabolism of glucose, lipids, and energy expenditure. We hypothesized that BA concentrations and related gene expression would be altered in lean (low-fat diet fed; LFD) vs diet-induced obese (high-fat diet fed; HFD) groups of mice and that some detected changes would remain after weight loss in an HFD group switched to the LFD (SW). Taurine conjugates dominated the bile acid composition of the liver, epididymal white adipose tissue (eWAT), and hypothalamus, with the latter having lower levels (similar to 95%, similar to 95%, and similar to 80%, respectively; P