Role of M-tuberculosis RD-1 region encoded secretory proteins in protective response and virulence
Role of M-tuberculosis RD-1 region encoded secretory proteins in protective response and virulence
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DOI：
10.1016/j.tube.2008.05.002
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发表时间：
2008-11-01
期刊：
影响因子：
3.2
通讯作者：
Sharma, Pawan
中科院分区：
文献类型：
--
作者：
Ganguly, Niladri;Siddiqui, Imran;Sharma, Pawan
与结核分枝杆菌基因组差异-1区(RD-1)相对应的一个横跨开放阅读框Rv3871-Rv3879c的基因片段全部缺失。卡介苗(BCG)疫苗株对牛分枝杆菌的致病作用，表明这可能是导致牛分枝杆菌致弱的主要缺失事件。因此，RD-1基因被认为在结核分枝杆菌的发病机制中起关键作用。该区域编码的两种最主要的分泌蛋白是。CFP-10(Rv3874)和ESAT-6(Rv3875)被广泛评价为S候选疫苗，并作为抗原用于结核病的诊断。然而，最近的一些报道表明，它们可能在巨噬细胞和树突状细胞功能失活中起作用。大量的最新文献对这些蛋白可能用来下调正常巨噬细胞功能的各种机制及其对结核分枝杆菌毒力的可能贡献提供了线索。这篇综述再次强调了这两种分泌型分枝杆菌的双重功能。蛋白质，即它们既具有T细胞激活功能，又具有巨噬细胞灭活功能。(C)2008爱思唯尔有限公司。保留所有权利。
A gene fragment corresponding to the region of difference-1 (RD-1) of the Mycobacterium tuberculosis genome, spanning open reading frames Rv3871 to Rv3879c, is missing in all. bacillus Calmette-Guerin (BCG) vaccine strains of M. bovis, indicating that this was perhaps the primary deletion event responsible for attenuation of virulent M. bovis. The RD-1 locus has, therefore, been considered crucial in the pathogenesis of M. tuberculosis. Two most predominant secretory proteins encoded by this region viz. CFP-10 (Rv3874) and ESAT-6 (Rv3875) are being widely evaluated as candidate vaccine(s) and used as antigens in the diagnosis of tuberculosis. However, several recent reports have implicated their putative role in deactivation of the macrophage and dendritic cell functions. A Large body of recent literature provides an inkling of various mechanisms these proteins might use to down regulate normal macrophage functions and their possible contribution to virulence of M. tuberculosis. This review re-emphasizes the suggestion about the dual function of these two secreted mycobacterial. proteins, viz., they have both T-cell activation and macrophage deactivation functions. (C) 2008 Elsevier Ltd. All rights reserved.