MAGNETIC-RESONANCE MICROSCOPY OF EMBRYONIC-CELL LINEAGES AND MOVEMENTS
MAGNETIC-RESONANCE MICROSCOPY OF EMBRYONIC-CELL LINEAGES AND MOVEMENTS
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DOI：
10.1126/science.7508143
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发表时间：
1994-02-04
期刊：
影响因子：
56.9
通讯作者：
FRASER, SE
中科院分区：
文献类型：
--
作者：
JACOBS, RE;FRASER, SE
Key events in vertebrate embryogenesis are difficult to observe in many species. High-resolution magnetic resonance imaging was used to follow cell movements and lineages in developing frog embryos. A single cell was injected at the 16-cell stage with a contrast agent, based on the gadolinium chelate gadolinium-diethylenetriamine pentaacetic acid-dextran. The labeled progeny cells could be followed uniquely in three-dimensional magnetic resonance images, acquired from the embryo over several days. The results show that external ectodermal and internal mesodermal tissues extend at different rates during amphibian gastrulation and neurulation.
