Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study
Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study
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DOI：
10.1002/oby.21422
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发表时间：
2016-04-01
期刊：
影响因子：
6.9
通讯作者：
Mathers, John C.
中科院分区：
文献类型：
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作者：
Celis-Morales, Carlos;Marsaux, Cyril F. M.;Mathers, John C.
ObjectiveTo研究FTO基因座对肥胖相关性状的影响是否可以通过体力活动（PA）levels in European adults.MethodsOf 1，607 Food 4 Me参与者随机分组，其中1，280人进行了FTO基因型（rs 9939609）和PA数据。使用加速度计客观测量PA（TracmorD，Philips），而人体测量测量[BMI和腰围（WC）]通过互联网自我报告。（95%CI：0.14-2.04），P=0.024]，BMI [：0.54 kgm（-2），（0.23-0.83），P
ObjectiveTo examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults.MethodsOf 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet.ResultsFTO genotype was associated with a higher body weight [: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P=0.024], BMI [: 0.54 kgm(-2), (0.23-0.83), P