Locomotion and conditioned place preference produced by acute intravenous amphetamine: role of dopamine receptors and individual differences in amphetamine self-administration
Locomotion and conditioned place preference produced by acute intravenous amphetamine: role of dopamine receptors and individual differences in amphetamine self-administration
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DOI：
10.1007/s002130050917
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发表时间：
1999-03-01
影响因子：
3.4
通讯作者：
Bevins, RA
中科院分区：
文献类型：
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作者：
Bardo, MT;Valone, JM;Bevins, RA
虽然以前的研究表明，多巴胺（DA）拮抗剂阻断安非他明的奖励，这些研究利用动物模型，涉及重复暴露于安非他明。本研究探讨了DA受体拮抗剂对大鼠急性静脉注射苯丙胺产生的单次条件性位置偏爱（CPP）的影响。在第一个实验中，用颈静脉导管准备大鼠，然后接受与CPP装置的一个隔室配对的安非他明（0.1-3 mg/kg）的急性IV注射。相对于假手术对照组（无IV导管），安非他明产生的自发活动和CPP的剂量依赖性增加。另外两项实验表明，在条件反射试验中，用D-1 DA拮抗剂SCH-23390（0.025和0.25 mg/kg）或D-2 DA拮抗剂依替氯必利（0.2和2 mg/kg）预处理大鼠可完全阻断苯丙胺的两种作用。在最后的实验中，单次试验安非他明CPP没有预测随后的自我管理IV安非他明（10-50微克/输液）使用固定比例（FR）1或渐进比例（PR）的强化计划。因此，虽然共享一个类似的DA受体机制，目前的研究结果表明，单次试验CPP和自我管理是分离的IV安非他明的影响。
Although previous studies have shown that dopamine (DA) antagonists block amphetamine reward, these studies have utilized animal models that involve repeated exposures to amphetamine. The present investigation examined the effect of DA antagonists on single-trial conditioned place preference (CPP) produced by acute intravenous (IV) amphetamine in rats. In the first experiment, rats were prepared with a jugular catheter and then received an acute IV injection of amphetamine (0.1-3 mg/kg) paired with one compartment of a CPP apparatus. Relative to sham controls (no IV catheter), amphetamine produced a dose-dependent increase in locomotor activity and CPP. Two further experiments demonstrated that both effects of amphetamine were completely blocked by pretreating rats with the D-1 DA antagonist SCH-23390 (0.025 and 0.25 mg/kg) or the D-2 DA antagonist eticlopride (0.2 and 2 mg/kg) on the conditioning trial. In a final experiment, single-trial amphetamine CPP did not predict subsequent self-administration of IV amphetamine (10-50 mu g/infusion) using either a fixed ratio (FR) 1 or progressive ratio (PR) schedule of reinforcement. Thus, while sharing a similar DA receptor mechanism, the present results indicate that single-trial CPP and self-administration are dissociable effects of IV amphetamine.