A point process approach to identifying and tracking transitions in neural spiking dynamics in the subthalamic nucleus of Parkinson's patients
A point process approach to identifying and tracking transitions in neural spiking dynamics in the subthalamic nucleus of Parkinson's patients
复制标题
DOI：
10.1063/1.4818546
复制
发表时间：
2013-12-01
期刊：
影响因子：
2.9
通讯作者：
Eden, Uri T.
中科院分区：
文献类型：
--
作者：
Deng, Xinyi;Eskandar, Emad N.;Eden, Uri T.
了解节律动力学在正常和疾病大脑功能中的作用是神经电生理学研究的一个重要领域。识别和跟踪与棘波序列相关的节律变化是一个额外的挑战，因为连续值神经记录的标准方法--如局部场电位、脑磁图和脑电数据--需要假设，而这些假设通常不适用于点过程数据。此外，脉冲序列依赖历史的结构的细微变化已被证明导致有节奏的放电模式的强劲变化。在这里，我们提出了一个点过程建模框架来描述棘波序列中有节奏的尖峰动态，测试这些动态的统计显著变化，并跟踪这些变化的时间演变。我们首先构建了一个包含放电历史的两状态点过程模型，并发展了一个似然比检验来检测放电结构的变化。然后，我们应用自适应状态空间滤波器和平滑器来跟踪这些随时间的变化。我们用一项模拟研究以及记录在帕金森病患者执行手臂运动任务的丘脑底核的实验数据来说明我们的方法。我们的分析表明，在手臂运动任务中，神经元经历了一种复杂的峰强度调制模式，最初的特征是在峰后20-40ms释放抑制控制，随后在峰后40-60ms兴奋影响减弱。(C)2013 AIP出版有限责任公司。
Understanding the role of rhythmic dynamics in normal and diseased brain function is an important area of research in neural electrophysiology. Identifying and tracking changes in rhythms associated with spike trains present an additional challenge, because standard approaches for continuous-valued neural recordings-such as local field potential, magnetoencephalography, and electroencephalography data-require assumptions that do not typically hold for point process data. Additionally, subtle changes in the history dependent structure of a spike train have been shown to lead to robust changes in rhythmic firing patterns. Here, we propose a point process modeling framework to characterize the rhythmic spiking dynamics in spike trains, test for statistically significant changes to those dynamics, and track the temporal evolution of such changes. We first construct a two-state point process model incorporating spiking history and develop a likelihood ratio test to detect changes in the firing structure. We then apply adaptive state-space filters and smoothers to track these changes through time. We illustrate our approach with a simulation study as well as with experimental data recorded in the subthalamic nucleus of Parkinson's patients performing an arm movement task. Our analyses show that during the arm movement task, neurons underwent a complex pattern of modulation of spiking intensity characterized initially by a release of inhibitory control at 20-40 ms after a spike, followed by a decrease in excitatory influence at 40-60 ms after a spike. (C) 2013 AIP Publishing LLC.