Ferritin Concentrations, Metabolic Syndrome, and Type 2 Diabetes in Middle-Aged and Elderly Chinese
Ferritin Concentrations, Metabolic Syndrome, and Type 2 Diabetes in Middle-Aged and Elderly Chinese
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DOI：
10.1210/jc.2008-1159
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发表时间：
2008-12-01
影响因子：
5.8
通讯作者：
Lin, Xu
中科院分区：
文献类型：
--
作者：
Sun, Liang;Franco, Oscar H.;Lin, Xu
内容：铁蛋白浓度升高经常与糖尿病的既定风险因素（包括肥胖、代谢综合征、慢性炎症和循环脂肪因子改变）相关。然而，很少有研究系统地评价这些危险因素对铁蛋白-糖尿病相关性的影响，特别是在中国人群中。目的：我们的目的是在中国中老年人群中研究铁蛋白浓度升高是否与代谢综合征和2型糖尿病的高风险相关，以及肥胖、炎症、设计和方法：我们于2005年在北京和上海对3289名年龄在50-70岁的参与者进行了基于人群的横断面调查。空腹血浆铁蛋白，葡萄糖，胰岛素，血脂，糖化血红蛋白，炎症标志物，脂肪因子和饮食profile.Results：中位数铁蛋白浓度为155.7 ng/ml的男性和111.9 ng/ml的女性。多重校正后，铁蛋白最高四分位数的2型糖尿病（OR 3.26，95%置信区间2.36-4.51）和代谢综合征[OR 2.80（95%置信区间2.24-3.49）]的比值比（OR）显著高于最低四分位数。这些协会仍然显着的饮食因素，身体质量指数，炎症标志物，和adipokines.Conclusions进一步调整后：循环铁蛋白浓度升高与2型糖尿病和代谢综合征的高风险在中老年中国独立的肥胖，炎症，adipokines，和其他危险因素。我们的数据支持铁超载对代谢性疾病的关键作用，即使在一个缺铁患病率相对较高的国家。（临床内分泌代谢杂志93：4690-4696，2008）
Context: Elevated ferritin concentrations frequently cluster with well-established risk factors of diabetes including obesity, metabolic syndrome, chronic inflammation, and altered circulating adipokines. Few studies, however, have systematically evaluated the effect of these risk factors on ferritin-diabetes association, particularly in Chinese populations.Objective: We aimed to investigate, in a middle-aged and elderly Chinese population, whether elevated ferritin concentrations are associated with higher risk of metabolic syndrome and type 2 diabetes and to what extent the associations were influenced by obesity, inflammation, and adipokines.Design and Methods: We conducted a population-based, cross-sectional survey of 3289 participants aged 50-70 yr in Beijing and Shanghai in 2005. Fasting plasma ferritin, glucose, insulin, lipid profile, glycohemoglobin, inflammatory markers, adipokines, and dietary profile were measured.Results: Median ferritin concentrations were 155.7 ng/ml for men and 111.9 ng/ml for women. After multiple adjustment, the odds ratios (ORs) were substantially higher for type 2 diabetes (OR 3.26, 95% confidence interval 2.36-4.51) and metabolic syndrome [OR 2.80 (95% confidence interval 2.24-3.49)] in the highest ferritin quartile compared with those in the lowest quartile. These associations remained significant after further adjustment for dietary factors, body mass index, inflammatory markers, and adipokines.Conclusions: Elevated circulating ferritin concentrations were associated with higher risk of type 2 diabetes and metabolic syndrome in middle-aged and elderly Chinese independent of obesity, inflammation, adipokines, and other risk factors. Our data support the crucial role of iron overload for metabolic diseases, even in a country with relatively high prevalence of iron deficiency. (J Clin Endocrinol Metab 93: 4690-4696, 2008)