Experimental neurobiology of central nervous system trauma.
Experimental neurobiology of central nervous system trauma.
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发表时间：
1993
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通讯作者：
Alan I. Faden
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作者：
Alan I. Faden
脑或脊髓的创伤性损伤通过至少三种机制引起不可逆的组织损伤：通过神经元或其投射的机械破坏的后果;通过由创伤引发的生物化学或代谢变化;以及通过反应性炎症或神经胶质变化。在过去的十年中，已经积累了大量的数据与创伤后组织损伤相关的细胞和生化事件。这导致了应用药理学策略来限制继发性损伤和随后的神经功能缺损。这些研究首次有效地治疗了人类脊髓损伤，其他有希望的治疗方法正在临床前后期或早期临床开发中。
Traumatic injuries to the brain or spinal cord cause irreversible tissue damage by at least three mechanisms: through consequences of mechanical disruption of neurons or their projections; through biochemical or metabolic changes that are initiated by the trauma; and through reactive inflammatory or gliotic changes. During the past decade, considerable data have been accumulated regarding cellular and biochemical events associated with posttraumatic tissue damage. This has led to the application of pharmacological strategies to limit secondary injury and subsequent neurological deficits. Such research has resulted in the first effective treatment of human spinal cord injury, with other promising treatments in late preclinical or early clinical development.