Prostate and metastasis diffusion volume based on apparent diffusion coefficient as a prognostic factor in Hormone-naive prostate cancer
Prostate and metastasis diffusion volume based on apparent diffusion coefficient as a prognostic factor in Hormone-naive prostate cancer
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基于表观扩散系数的前列腺和转移扩散体积作为激素初治前列腺癌的预后因素
DOI：
10.1007/s10585-023-10200-2
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Fujii Y.
中科院分区：
文献类型：
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作者：
Fujiwara M;Yoshida S;Takahara T;Soma T;Nakamura Y;Ishikawa Y;Fukuda S;Waseda Y;Tanaka H;Yokoyama M;Fujii Y.
在本研究中，为了评估全身 DWI (WB-DWI) 作为转移性激素初治前列腺癌 (mHNPC) 成像生物标志物的效用，我们根据表观扩散系数 (ADC) 值评估了肿瘤扩散体积。本回顾性分析评估了从 62 名 mHNPC 患者获得的 WB-DWI 结果。基于 WB-DWI 评估前列腺和转移性肿瘤扩散体积（分别为 pDV 和 mDV）与去势抵抗性生存 (CFS) 的关联。还检查了基于 ADC 值的 pDV 和 mDV 预测 CFS 的有用性。随访期间，22名患者进展为去势抵抗性前列腺癌，中位CFS为42.6个月。中位 mDV 和 pDV 分别为 6.7 和 12.6 mL。 mDV 是 CFS 的显着预测因子（风险比 [HR]：2.75；p= 0.022），而 pDV 不显着。当 DV 按 ADC 值 (× 10− 3mm2/s) 为 0.4–1.0 和 1.0–1.8 (× 10− 3mm2/s) 分组时，ADC 值 (× 10− 3mm2/s) 为 0.4–1.0 (mDV0.4−1.0) 的 mDV 与总 mDV 相比显示出与 CFS 更有利的相关性。多变量分析显示，mDV0.4−1.0和Gleason分级组与CFS具有统计学显着相关性（HR：4.0；p= 0.004，HR：3.4；p= 0.006），而pDV与ADC值（×10− 3mm2/s）0.4–1.0没有显着相关性。 mDV 可用于预测 mHNPC 患者的 CFS。当基于 ADC 值时，mDV 可能是更好的成像生物标志物。
In this study, to assess the utility of whole-body DWI (WB-DWI) as an imaging biomarker for metastatic hormone-naïve prostate cancer (mHNPC), we evaluated tumor diffusion volume based on apparent diffusion coefficient (ADC) values. WB-DWI results obtained from 62 mHNPC patients were evaluated in this retrospective analysis. The association with castration resistant–free survival (CFS) was evaluated for both prostate and metastatic tumor diffusion volume (pDV and mDV, respectively) based on WB-DWI. The usefulness of pDV and mDV based on ADC values to predict CFS was also examined. During the follow-up period, 22 patients progressed to castration-resistant prostate cancer, and the median CFS was 42.6 months. The median mDV and pDV were 6.7 and 12.6 mL, respectively. mDV was a significant predictor of CFS (hazard ratio [HR]: 2.75;p= 0.022), while pDV was not significant. When DV was divided into groups by ADC values (× 10− 3mm2/s) of 0.4–1.0 and 1.0–1.8 (× 10− 3mm2/s), mDV with ADC values (× 10− 3mm2/s) of 0.4–1.0 (mDV0.4−1.0) showed a more favorable association with CFS compared to total mDV. On multivariate analysis, mDV0.4−1.0and Gleason grade group had a statistically significant association with CFS (HR: 4.0;p= 0.004, and HR: 3.4;p= 0.006, respectively), while pDV with ADC values (× 10− 3mm2/s) of 0.4–1.0 did not have a significant association. mDV is useful for predicting CFS in mHNPC patients. mDV may be a better imaging biomarker when based on ADC values.