Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir.
Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir.
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来自接受阿昔洛韦治疗的严重免疫功能低下患者的单纯疱疹病毒 DNA 聚合酶突变体的表征。
作者：
P. Collins;B. Larder;N. Oliver;S. Kemp;I. Smith;G. Darby
一系列的单纯疱疹病毒分离物回收骨髓移植患者谁接受长期无环鸟苷治疗无痛单纯疱疹口腔和咽喉溃疡。14株分离株中有10株对阿昔洛韦耐药，对膦酰乙酸部分耐药。生化特性表明，耐药性是由于病毒DNA聚合酶的改变。空斑纯化的耐药病毒分离株的聚合酶基因的DNA序列分析显示，与空斑纯化的敏感分离株的基因序列相比，单核苷酸的变化。这一单碱基的变化导致预测的氨基酸取代的甘氨酸丝氨酸残基编号841，推定的功能区的聚合酶。
A series of herpes simplex virus isolates were recovered from a bone marrow transplant patient who received prolonged acyclovir therapy for indolent herpes simplex mouth and throat ulceration. Of 14 isolates received 10 were resistant to acyclovir and partially resistant to phosphonoacetic acid. Biochemical characterization revealed that resistance was due to an alteration in the virus DNA polymerase. DNA sequence analysis of the polymerase gene of a plaque-purified resistant virus isolate revealed a single nucleotide change when compared with the sequence of the gene of a plaque-purified sensitive isolate. This single base change resulted in a predicted amino acid substitution of Gly to Ser at residue number 841, a putative functional region of the polymerase.
口服阿昔洛韦治疗免疫功能低下的骨髓移植受者的皮肤粘膜单纯疱疹病毒感染。
影响因子：
39.2
作者：
Shepp,DH;Newton,BA;Dandliker,PS;Flournoy,N;Meyers,JD
通讯作者：
Meyers,JD
静脉注射阿昔洛韦治疗免疫功能低下宿主皮肤粘膜单纯疱疹病毒感染的多中心合作试验。
DOI：
10.1016/0002-9343(82)90097-3
发表时间：
1982
期刊：
The American journal of medicine
影响因子：
--
作者：
Meyers,JD;Wade,JC;Mitchell,CD;Saral,R;Lietman,PS;Durack,DT;Levin,MJ;Segreti,AC;BalfourJr,HH
通讯作者：
BalfourJr,HH
免疫功能低下宿主中单纯疱疹病毒引起的感染：自然史和局部阿昔洛韦治疗。
DOI：
10.1093/infdis/150.3.323
发表时间：
1984
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Whitley,RJ;Levin,M;Barton,N;Hershey,BJ;Davis,G;Keeney,RE;Whelchel,J;Diethelm,AG;Kartus,P;Soong,SJ
通讯作者：
Soong,SJ