The effect of a multicomponent intervention to promote community activity on cognitive function in older adults with mild cognitive impairment: A randomized controlled trial
The effect of a multicomponent intervention to promote community activity on cognitive function in older adults with mild cognitive impairment: A randomized controlled trial
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DOI：
10.1016/j.ctim.2018.11.011
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发表时间：
2019-02-01
影响因子：
3.6
通讯作者：
Shimada, Hiroyuki
中科院分区：
文献类型：
--
作者：
Bae, Seongryu;Lee, Sangyoon;Shimada, Hiroyuki
目的：本研究旨在探讨一种多成分干预措施的有效性，该措施结合了身体、认知和社会活动，旨在促进社区活动，改善轻度认知障碍（MCI）老年人的认知功能。设计：单盲随机对照试验。设置2017年4月至9月，共有83名日本MCI老年人参加了本研究。参与者被随机分配到多因素干预组（n = 41）或健康教育对照组（n = 42），多因素干预组每周两次利用社区资源参加90分钟的身体、认知或社会活动。主要结果是认知功能，次要结果是握力、步行速度、抑郁症状、体力活动、户外活动次数和谈话时间。使用线性混合模型的分析显示，与对照组相比，干预组在干预后的空间工作记忆（p = 0.024）有显着更大的改善。在对照组中，中度至剧烈体力活动（p = 0.048）和步数（p = 0.059）的时间从基线干预后减少，而在干预组中，基线保持不变。在其他主要和次要outcome.Conclusions干预后，未发现组间显著差异：本研究表明，24周的多组分干预计划是有效的改善空间工作记忆和维持体力活动的老年人MCI。需要进行后续调查，以确定持续的身体，认知和社会活动是否可以预防老年人痴呆或逆转MCI。
Objectives: This study aimed to examine the effectiveness of a multicomponent intervention combining physical, cognitive, and social activities developed to promote community activity in improving cognitive function in older adults with mild cognitive impairment (MCI).Design: Single-blind randomized controlled trial.Setting A total of 83 Japanese older adults with MCI participated in the study from April to September 2017.Interventions: Participants were randomly assigned to either the multicomponent intervention group (n = 41), attending 90-minute physical, cognitive, or social activity sessions using community resources twice weekly, or the health education control group (n = 42).Outcomes: The primary outcomes were cognitive functions, and the secondary outcomes were grip strength, walking speed, depressive symptoms, physical activities, number of outdoor activities, and conversation time.Results: Analysis using linear mixed models revealed significantly greater improvements in the intervention group in spatial working memory (p = 0.024) following intervention compared with the control group. Time spent in moderate-to-vigorous physical activity (p = 0.048) and step count (p = 0.059) decreased from the baseline post-intervention in the control group, whereas the baseline was maintained in the intervention group. No significant between-group differences were found post-intervention in the other primary and secondary outcomes.Conclusions: This study showed that a 24-week multicomponent intervention program was effective in improving spatial working memory and maintaining physical activity in older adults with MCI. A follow-up investigation is required to determine whether continuation of physical, cognitive, and social activity can prevent dementia or reverse MCI in older adults.