Targeting Stromal-Cancer Cell Crosstalk Networks in Ovarian Cancer Treatment.
Targeting Stromal-Cancer Cell Crosstalk Networks in Ovarian Cancer Treatment.
复制标题
靶向卵巢癌治疗中的基质癌细胞串扰网络。
DOI：
10.3390/biom6010003
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发表时间：
2016-01-06
期刊：
影响因子：
5.5
通讯作者：
Mok SC
中科院分区：
文献类型：
--
作者：
Yeung TL;Leung CS;Li F;Wong SS;Mok SC
卵巢癌是一种组织学、临床和分子多样化的疾病，五年生存率低于 30%。据估计，2015年美国将诊断出约21,980例上皮性卵巢癌新病例，并有14,270人死亡，使其成为最致命的妇科恶性肿瘤。卵巢肿瘤组织由癌细胞和不同基质细胞的集合组成。越来越多的证据表明间质参与在卵巢癌发病机制中很重要。因此，基质特异性信号通路、基质衍生因子和肿瘤基质中的遗传变化为改善卵巢癌的诊断和治疗提供了独特的机会。癌症相关成纤维细胞（CAF）是肿瘤基质的主要成分之一，已证明在肿瘤进展中具有支持作用。在这篇综述中，我们重点介绍了卵巢癌细胞和基质细胞之间的各种类型的信号串扰，特别是 CAF。除了评估信号串扰在卵巢癌进展中的重要性之外，我们还讨论了可用于靶向促进肿瘤的信号串扰的方法以及如何将这些方法转化为潜在的卵巢癌治疗。
Ovarian cancer is a histologically, clinically, and molecularly diverse disease with a five-year survival rate of less than 30%. It has been estimated that approximately 21,980 new cases of epithelial ovarian cancer will be diagnosed and 14,270 deaths will occur in the United States in 2015, making it the most lethal gynecologic malignancy. Ovarian tumor tissue is composed of cancer cells and a collection of different stromal cells. There is increasing evidence that demonstrates that stromal involvement is important in ovarian cancer pathogenesis. Therefore, stroma-specific signaling pathways, stroma-derived factors, and genetic changes in the tumor stroma present unique opportunities for improving the diagnosis and treatment of ovarian cancer. Cancer-associated fibroblasts (CAFs) are one of the major components of the tumor stroma that have demonstrated supportive roles in tumor progression. In this review, we highlight various types of signaling crosstalk between ovarian cancer cells and stromal cells, particularly with CAFs. In addition to evaluating the importance of signaling crosstalk in ovarian cancer progression, we discuss approaches that can be used to target tumor-promoting signaling crosstalk and how these approaches can be translated into potential ovarian cancer treatment.