Effect of brussels sprouts and cabbage on drug conjugation
Effect of brussels sprouts and cabbage on drug conjugation
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球芽甘蓝和卷心菜对药物结合的影响
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
A. Kappas
中科院分区：
文献类型：
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作者：
E. Pantuck;C. Pantuck;K. Anderson;L. Wattenberg;A. Conney;A. Kappas
十名健康受试者被喂食三种饮食，每次 10 天：对照饮食、含卷心菜和抱子甘蓝的饮食，以及第二次对照饮食。每个饮食方案的第 7 天服用奥沙西泮，第 10 天服用对乙酰氨基酚。测试饮食刺激了对乙酰氨基酚的代谢，至少部分是通过增强葡萄糖醛酸化作用来刺激对乙酰氨基酚的代谢，平均血浆 AUC 降低 16%，平均代谢清除率增加 17%，用药后 1 小时至 11 小时血浆中对乙酰氨基酚葡萄糖醛酸与对乙酰氨基酚的比率增加，对乙酰氨基酚葡萄糖醛酸的平均 24 小时尿回收率增加 8%，当受试者第二次接受对照饮食。对乙酰氨基酚到硫酸对乙酰氨基酚的代谢没有类似的变化。当受试者食用测试饮食时，24 小时尿中半胱氨酸结合物和 3-甲氧基对乙酰氨基酚硫酸盐（次要氧化途径的终产物）（前者涉及有毒中间体）的回收率分别降低了 13% 和 22%。卷心菜和球芽甘蓝导致奥沙西泮的平均血浆 AUC 降低 17%，平均代谢清除率增加 19%，但该药物的平均血浆 t½ 没有变化，血浆中奥沙西泮葡萄糖苷酸与奥沙西泮的比例也没有变化。
Ten healthy subjects were fed three diets for 10 days each: a control diet, a cabbage and brussels sprouts–containing diet, and the control diet a second time. Oxazepam was taken on day 7 and acetaminophen on day 10 of each dietary regimen. The test diet stimulated the metabolism of acetaminophen, at least in part by enhanced glucuronidation, as evidenced by a 16% decrease in mean plasma AUC, a 17% increase in mean metabolic clearance rate, an increased ratio of acetaminophen glucuronide to acetaminophen in plasma from 1 to 11 hr after drug and an 8% increase in mean 24‐hr urinary recovery of acetaminophen glucuronide, which returned toward control when the subjects were fed the control diet a second time. There were no comparable changes in the metabolism of acetaminophen to acetaminophen sulfate. When the subjects ate the test diet, 24‐hr urinary recovery of the cysteine conjugate and of 3‐methoxyacetaminophen sulfate, end‐products of minor oxidative pathways, the former involving a toxic intermediate, decreased 13% and 22%. Cabbage and brussels sprouts induced a 17% decrease in mean plasma AUC and a 19% increase in mean metabolic clearance rate for oxazepam, but there was no change in mean plasma t½ for this drug, nor was there a change in ratio in plasma of oxazepam glucuronide to oxazepam.