Prenylated dihydrochalcones from Boronia bipinnata that inhibit the malarial parasite enzyme target hemoglobinase II.
Prenylated dihydrochalcones from Boronia bipinnata that inhibit the malarial parasite enzyme target hemoglobinase II.
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DOI：
10.1021/np8002707
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发表时间：
2008-07
影响因子：
5.1
通讯作者：
A. Carroll;G. Fechner;Jill Smith;G. Guymer;R. Quinn
中科院分区：
文献类型：
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作者：
A. Carroll;G. Fechner;Jill Smith;G. Guymer;R. Quinn
对植物和海洋无脊椎动物提取物文库进行高通量筛选，以寻找抑制疟疾寄生虫酶靶血红蛋白酶II的天然产物，结果从昆士兰州灌木Boronia bipinnata的地上部分分离出两种新的活性异戊二烯化查耳酮，bipinnatone A（1）和B（2）。通过2D NMR和高分辨率ESIMS数据的解析，对它们的结构进行了归属。化合物1和2抑制血红蛋白酶II，IC50值分别为64和52 μ M。
High-throughput screening of a plant and marine invertebrate extract library to find natural products that inhibit the malarial parasite enzyme target hemoglobinase II led to the isolation of two new active prenylated chalcones, bipinnatones A (1) and B (2), from aerial parts of the Queensland shrub Boronia bipinnata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 inhibited hemoglobinase II with IC 50 values of 64 and 52 microM, respectively.