Psychosocial factors and interleukin-6 among women with advanced ovarian cancer
Psychosocial factors and interleukin-6 among women with advanced ovarian cancer
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DOI：
10.1002/cncr.21147
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发表时间：
2005-07-15
期刊：
影响因子：
6.2
通讯作者：
Lubaroff, DM
中科院分区：
文献类型：
--
作者：
Costanzo, ES;Lutgendorf, SK;Lubaroff, DM
背景心理压力、抑郁、社会支持和白细胞介素-6（IL-6，一种促炎细胞因子）之间的关系已在人类和动物中得到证实。由于IL-6升高与卵巢癌患者的预后较差相关，并与卵巢癌的转移有关，因此本研究探讨了晚期卵巢癌患者的心理社会因素与IL-6之间的关系。61名卵巢癌患者在手术前完成了社会支持、痛苦情绪和生活质量的评估。术前抽取外周血，并测定血浆中的IL-6。腹水样本也进行了IL-6的一个子集的患者。患者的IL-6水平和抑郁情绪均升高。在对年龄和疾病阶段的影响进行统计学调整后，社会依恋与外周血中IL-6水平较低相关（P = 0.03），而健康相关生活质量较差与IL-6水平较高相关（不同测量值的P值范围为0.01至0.03）。腹水中也发现了这种关系。外周血IL-6水平与腹水IL-6水平呈显著正相关（P < 0.001），提示外周血IL-6水平可反映肿瘤部位IL-6水平。结果表明，社会支持可能对IL-6升高发挥保护作用，IL-6可能是卵巢癌患者健康相关生活质量的独立标志物。涉及IL-6的过程代表了行为因素可能导致卵巢癌妇女疾病结局的可能途径。(c)2005年美国癌症协会。
BACKGROUND. Relations among psychological stress, depression, social support, and interleukin-6 (IL-6, a proinflammatory cytokine) have been documented in humans and animals. Because elevated IL-6 is associated with a poorer prognosis among ovarian cancer patients and has been implicated in the metastasis of ovarian cancer, the current study examined relations between psychosocial factors and IL-6 among women with advanced-stage ovarian cancer.METHODS. Sixty-one ovarian cancer patients completed assessments of social support, distressed mood, and quality of life before surgery. Peripheral blood was drawn preoperatively, and the plasma was assayed for IL-6. Ascites samples were also assayed for IL-6 for a subset of patients.RESULTS. Both IL-6 levels and distressed mood were elevated among patients. After statistically adjusting effects of age and disease stage, social attachment was associated with lower levels of IL-6 in peripheral blood (P = 0.03), whereas poorer health-related quality of life was associated with higher IL-6 (P values ranged from 0.01 to 0.03 on different measures). This pattern of relations was also found in the ascites. Moreover, IL-6 levels in peripheral blood plasma correlated significantly with IL-6 in the ascites (P < 0.001), suggesting that peripheral IL-6 reflects IL-6 levels at the site of the tumor.CONCLUSIONS. Results suggest that social support may play a protective role with respect to IL-6 elevations, and IL-6 may be an independent marker of health-related quality of life among ovarian cancer patients. Processes involving IL-6 represent possible pathways by which behavioral factors may contribute to disease outcomes among women with ovarian cancer. (c) 2005 American Cancer Society.