Information flow between interacting human brains: Identification, validation, and relationship to social expertise
Information flow between interacting human brains: Identification, validation, and relationship to social expertise
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DOI：
10.1073/pnas.1421831112
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发表时间：
2015-04-21
影响因子：
11.1
通讯作者：
Meyer-Lindenberg, Andreas
中科院分区：
文献类型：
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作者：
Bilek, Edda;Ruf, Matthias;Meyer-Lindenberg, Andreas
社会互动是人类行为的基础，但对其神经基础的量化仍然具有挑战性。在这里，我们使用超扫描功能性磁共振成像（fMRI）研究在实时社会互动中的联合注意范式的人类二人组的大脑之间的信息流。在一个硬件设置，使沉浸式视听互动的主题链接功能磁共振成像扫描仪，我们的特点是跨脑连接组件是独特的互动的个人，识别信息流之间的发送者和接收者的颞顶交界处。我们在一个独立的样本中复制了这些发现，并通过证明跨脑连接与社会行为的一个关键现实衡量标准相关来验证我们的方法。总之，我们的研究结果支持了人类特定的皮层区域在二元互动的大脑动力学中的核心作用，并提供了一种方法，以最小的先验假设，对健康和不安的人类社会行为的神经基础进行非侵入性检查。
Social interactions are fundamental for human behavior, but the quantification of their neural underpinnings remains challenging. Here, we used hyperscanning functional MRI (fMRI) to study information flow between brains of human dyads during real-time social interaction in a joint attention paradigm. In a hardware setup enabling immersive audiovisual interaction of subjects in linked fMRI scanners, we characterize cross-brain connectivity components that are unique to interacting individuals, identifying information flow between the sender's and receiver's temporoparietal junction. We replicate these findings in an independent sample and validate our methods by demonstrating that cross-brain connectivity relates to a key real-world measure of social behavior. Together, our findings support a central role of human-specific cortical areas in the brain dynamics of dyadic interactions and provide an approach for the noninvasive examination of the neural basis of healthy and disturbed human social behavior with minimal a priori assumptions.