Stroke Risk of Blood Pressure Indices Determined by Home Blood Pressure Measurement The Ohasama Study
Stroke Risk of Blood Pressure Indices Determined by Home Blood Pressure Measurement The Ohasama Study
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DOI：
10.1161/strokeaha.108.546499
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发表时间：
2009-08-01
期刊：
影响因子：
8.3
通讯作者：
Imai, Yutaka
中科院分区：
文献类型：
--
作者：
Inoue, Ryusuke;Ohkubo, Takayoshi;Imai, Yutaka
背景与目的：本前瞻性队列研究的目的是探讨卒中与家庭血压测量测定的血压（BP）指数（收缩压[SBP]、舒张压[DBP]、平均血压和脉压[PP]）之间的关系。方法：在日本农村人群中研究卒中与血压指数之间的关系。2369名无脑卒中史的受试者（40%为男性），年龄35岁（平均59岁）。采用Cox比例风险回归和似然比（LR）检验确定卒中与各指标的相关性。结果：在随访期间（平均11.7年），发生238例卒中。LR试验显示收缩压和平均血压与总卒中和缺血性卒中的相关性明显高于舒张压和心压(LR chi（2) >= 9.3，收缩压/平均血压P < 0.01，舒张压/心压LR chi(2) = 0.05）。与平均血压相比，收缩压与总卒中/缺血性卒中的相关性更强(收缩压（2)= 3.8,P = 0.05，平均血压(2)0.6）。PP与缺血性脑卒中的相关性略高于DBP (LR chi(2) = 7.5， P
Background and Purpose-The purpose of this prospective cohort study was to investigate associations between stroke and blood pressure (BP) indices (systolic BP [SBP], diastolic BP [DBP], mean BP, and pulse pressure [ PP]) determined by home BP measurement.Methods-Associations between stroke and BP indices were examined in a rural Japanese population. Home BP data of 2369 subjects (40% men) >= 35 years of age (mean, 59 years) without a history of stroke were obtained. Associations between stroke and each index were determined using Cox proportional hazards regression and the likelihood ratio (LR)test.Results-During follow-up (mean, 11.7 years), 238 strokes occurred. The LR test showed that SBP and mean BP were significantly more strongly associated with total and ischemic stroke than DBP and PP (LR chi(2) >= 9.3, P < 0.01 for SBP/mean BP, LR chi(2) = 0.05 for DBP/PP). SBP tended to be more strongly associated with total/ischemic stroke than mean BP (LR chi(2) = 3.8, P = 0.05 for SBP, LR chi(2) 0.6 for mean BP). PP tended to be slightly more strongly associated with ischemic stroke than DBP (LR chi(2) = 7.5, P